Recent issues in Varicella Zoster virus latency

Kennedy, P. G. E., Mogensen, T. H. and Cohrs, R. J. (2021) Recent issues in Varicella Zoster virus latency. Viruses, 13(10), 2018. (doi: 10.3390/v13102018)

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Varicella-zoster virus (VZV) is a human herpes virus which causes varicella (chicken pox) as a primary infection, and, following a variable period of latency in neurons in the peripheral ganglia, may reactivate to cause herpes zoster (shingles) as well as a variety of neurological syndromes. In this overview we consider some recent issues in alphaherpesvirus latency with special focus on VZV ganglionic latency. A key question is the nature and extent of viral gene transcription during viral latency. While it is known that this is highly restricted, it is only recently that the very high degree of that restriction has been clarified, with both VZV gene 63-encoded transcripts and discovery of a novel VZV transcript (VLT) that maps antisense to the viral transactivator gene 61. It has also emerged in recent years that there is significant epigenetic regulation of VZV gene transcription, and the mechanisms underlying this are complex and being unraveled. The last few years has also seen an increased interest in the immunological aspects of VZV latency and reactivation, in particular from the perspective of inborn errors of host immunity that predispose to different VZV reactivation syndromes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P. G. E., Mogensen, T. H., and Cohrs, R. J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Viruses
Published Online:07 October 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Viruses 13(10): 2018
Publisher Policy:Reproduced under a Creative Commons licence

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