Favipiravir and zanamivir cleared infection with influenza B in a severely immunocompromised child

Lumby, C. K. et al. (2020) Favipiravir and zanamivir cleared infection with influenza B in a severely immunocompromised child. Clinical Infectious Diseases, 71(7), e191-e194. (doi: 10.1093/cid/ciaa023) (PMID:32124919)

Abstract

A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.

• Item Type: Articles
• Additional Information: This work was supported by a Sir Henry Dale Fellowship, jointly funded by the Wellcome Trust and the Royal Society (grant numbers 101239/Z/13/Z and 101239/Z/13/A). C. K. L. was funded by a Wellcome Trust Studentship (grant number 105365/Z/14/Z). J. B. receives funding from the UCL/UCLH NIHR Biomedical Research Centre. C. J. R. I. reports funding from the Isaac Newton Trust.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Illingworth, Dr Chris
• Authors: Lumby, C. K., Zhao, L., Oporto, M., Best, T., Tutill, H., Shah, D., Veys, P., Williams, R., Worth, A., Illingworth, C. J. R., and Breuer, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: Clinical Infectious Diseases
• Publisher: Oxford University Press
• ISSN: 1058-4838
• ISSN (Online): 1537-6591
• Published Online: 03 March 2020
• Copyright Holders: Copyright © 2020 The Authors
• First Published: First published in Clinical Infectious Diseases 71(7): e191-e194
• Publisher Policy: Reproduced under a Creative Commons License