Toll, E. C., Murison, P. J. , Jones, A., Kingham, P. J., Sedaghati, T., Seifalian, A. M. and Birchall, M. (2014) The effect of low-dose tacrolimus on recurrent laryngeal nerve regeneration in pigs: a pilot study. Archives of Clinical and Experimental Surgery, 3(2), pp. 78-86. (doi: 10.5455/aces.20130427050406)
Full text not currently available from Enlighten.
Publisher's URL: https://www.ejmaces.com/abstract/the-effect-of-lowdose-tacrolimus-on-recurrent-laryngeal-nerve-regeneration-in-pigs-a-pilot-study-48551.html
Abstract
Objective: The functional neurotrophic effects of systemic tacrolimus in a sub-immunosuppressive regimen in the minipig model of laryngeal reinnervation were investigated. Methods: Right recurrent laryngeal nerve transection and phrenic-abductor branch of recurrent laryngeal nerve anastomosis were performed in two minipigs that were administered low-dose oral tacrolimus (0.125 mg/kg) for one month. Vocal cord abduction at four months was rated by two blinded expert assessors on a four-point Likert scale from poor (1) to complete (4), and compared with five fully matched historical control animals that received the same surgery but no other interventions. Results: Right vocal cord abduction was more complete in tacrolimus-treated animals than controls (mean abduction score 2.3 vs. 1.5, p=0.019). Conclusion: Tacrolimus may have an important role in laryngeal reinnervation following allograft transplantation, and low-dose regimens may have applications in cranial and peripheral nerve injuries or in the reinnervation of tissue-engineered laryngeal constructs, but further studies are required.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kingham, Dr Paul and Murison, Professor Pamela |
| Authors: | Toll, E. C., Murison, P. J., Jones, A., Kingham, P. J., Sedaghati, T., Seifalian, A. M., and Birchall, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Archives of Clinical and Experimental Surgery |
| Publisher: | ScopeMed |
| ISSN: | 2146-8133 |
| ISSN (Online): | 2146-8133 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details