Correlation of mechanical factors and gallbladder pain

Li, W.G., Luo, X.Y., Hill, N.A., Smythe, A., Chin, S.B., Johnson, A.G. and Bird, N.C. (2008) Correlation of mechanical factors and gallbladder pain. Computational and Mathematical Methods in Medicine, 9(1), pp. 27-45. (doi:10.1080/17486700701780266)

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Publisher's URL: http://dx.doi.org/10.1080/17486700701780266

Abstract

Acalculous biliary pain occurs in patients with no gallstones, but is similar to that experienced by patients with gallstones. Surgical removal of the gallbladder (GB) in these patients is only successful in providing relief of symptoms to about half of those operated on, so a reliable pain-prediction model is needed. In this paper, a mechanical model is developed for the human biliary system during the emptying phase, based on a clinical test in which GB volume changes are measured in response to a standard stimulus and a recorded pain profile. The model can describe the bile emptying behaviour, the flow resistance in the biliary ducts, the peak total stress, including the passive and active stresses experienced by the GB during emptying. This model is used to explore the potential link between GB pain and mechanical factors. It is found that the peak total normal stress may be used as an effective pain indicator for GB pain. When this model is applied to clinical data of volume changes due to Cholecystokinin stimulation and pain from 37 patients, it shows a promising success rate of 88.2% in positive pain prediction.

Item Type:Articles
Keywords:Gallbladder, total stress, gallbladder pain, gallstone, flow resistance, emptying
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Hill, Professor Nicholas
Authors: Li, W.G., Luo, X.Y., Hill, N.A., Smythe, A., Chin, S.B., Johnson, A.G., and Bird, N.C.
Subjects:Q Science > QA Mathematics
R Medicine > RC Internal medicine
Q Science > QH Natural history > QH301 Biology
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Computational and Mathematical Methods in Medicine
Publisher:Taylor and Francis
ISSN:1748-670X
ISSN (Online):1748-6718
Published Online:22 January 2008
Copyright Holders:Copyright © 2008 Taylor and Francis
First Published:First published in Computational and Mathematical Methods in Medicine 9(1):27-45
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
489101Exploring the Mechanisms of Human Gallbladder PainXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/G015651/1M&S - MATHEMATICS