Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2014) IL-4: an important cytokine in determining the fate of T cells. Biophysical Reviews, 6(1), pp. 111-118. (doi: 10.1007/s12551-013-0133-z) (PMID:28509961) (PMCID:PMC5427811)
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Abstract
The pleiotropic effect of cytokines has been well documented, but the effects triggered by unique cytokines in different T cell types are still under investigation. The most relevant findings on the influence of interleukin-4 (IL-4) on T cell activation, differentiation, proliferation, and survival of different T cell types are discussed in this review. The main aim of our study was to correlate the observed effect with the corresponding molecular mechanism induced on IL-4/IL-4R interaction, in an effort to understand how the same extracellular stimuli can trigger a wide spectrum of signaling pathways leading to different responses in each T cell type.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Da Silva Filho, Dr Joao |
| Authors: | Silva-Filho, J. L., Caruso-Neves, C., and Pinheiro, A. A. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Biophysical Reviews |
| Publisher: | Springer |
| ISSN: | 1867-2450 |
| ISSN (Online): | 1867-2469 |
| Published Online: | 09 January 2014 |
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