GABA B receptor-mediated regulation of dendro-somatic synergy in layer 5 pyramidal neurons

Schulz, J. M., Kay, J. W. , Bischofberger, J. and Larkum, M. E. (2021) GABA B receptor-mediated regulation of dendro-somatic synergy in layer 5 pyramidal neurons. Frontiers in Cellular Neuroscience, 15, 718413. (doi: 10.3389/fncel.2021.718413)

Abstract

Synergistic interactions between independent synaptic input streams may fundamentally change the action potential (AP) output. Using partial information decomposition, we demonstrate here a substantial contribution of synergy between somatic and apical dendritic inputs to the information in the AP output of L5b pyramidal neurons. Activation of dendritic GABAB receptors (GABABRs), known to decrease APs in vivo, potently decreased synergy and increased somatic control of AP output. Synergy was the result of the voltage-dependence of the transfer resistance between dendrite and soma, which showed a two-fold increase per 28.7 mV dendritic depolarization. GIRK channels activated by dendritic GABABRs decreased voltage-dependent transfer resistances and AP output. In contrast, inhibition of dendritic L-type Ca2+ channels prevented high-frequency bursts of APs, but did not affect dendro-somatic synergy. Finally, we show that NDNF-positive neurogliaform cells effectively control somatic AP via synaptic activation of dendritic GIRK channels. These results uncover a novel inhibitory mechanism that powerfully gates cellular information flow in the cortex.

• Item Type: Articles
• Additional Information: This work was supported by the Swiss National Science Foundation (SNSF, PP00A-102721 and 31003A_130694).
• Keywords: Neocortex, dendrite, interneuron, neurogliaform cells, GIRK channels, interhemispheric inhibition, L-type calcium channels, HCN channels – h current.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kay, Dr James
• Authors: Schulz, J. M., Kay, J. W., Bischofberger, J., and Larkum, M. E.
• College/School: College of Science and Engineering > School of Mathematics and Statistics
• Journal Name: Frontiers in Cellular Neuroscience
• Publisher: Frontiers Media
• ISSN: 1662-5102
• ISSN (Online): 1662-5102
• Copyright Holders: Copyright © 2021 Schulz, Kay, Bischofberger and Larkum
• First Published: First published in Frontiers in Cellular Neuroscience 15: 718413
• Publisher Policy: Reproduced under a Creative Commons License