The vectors of Plasmodium knowlesi and other simian malarias Southeast Asia: challenges in malaria elimination

Vythilingam, I., Chua, T. H., Liew, J. W. K., O’Mannin, B. and Ferguson, H. (2021) The vectors of Plasmodium knowlesi and other simian malarias Southeast Asia: challenges in malaria elimination. In: Rollinson, D. and Stothard, R. (eds.) Current Research on Naturally Transmitted Plasmodium knowlesi. Series: Advances in Parasitology (113). Elsevier, pp. 131-189. ISBN 9780323907279 (doi:10.1016/bs.apar.2021.08.005)

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Abstract

Plasmodium knowlesi, a simian malaria parasite of great public health concern has been reported from most countries in Southeast Asia and exported to various countries around the world. Currently P. knowlesi is the predominant species infecting humans in Malaysia. Besides this species, other simian malaria parasites such as P. cynomolgi and P. inui are also infecting humans in the region. The vectors of P. knowlesi and other Asian simian malarias belong to the Leucosphyrus Group of Anopheles mosquitoes which are generally forest dwelling species. Continual deforestation has resulted in these species moving into forest fringes, farms, plantations and human settlements along with their macaque hosts. Limited studies have shown that mosquito vectors are attracted to both humans and macaque hosts, preferring to bite outdoors and in the early part of the night. We here review the current status of simian malaria vectors and their parasites, knowledge of vector competence from experimental infections and discuss possible vector control measures. The challenges encountered in simian malaria elimination are also discussed. We highlight key knowledge gaps on vector distribution and ecology that may impede effective control strategies.

Item Type:Book Sections
Additional Information:Book series.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ferguson, Professor Heather
Authors: Vythilingam, I., Chua, T. H., Liew, J. W. K., O’Mannin, B., and Ferguson, H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Publisher:Elsevier
ISBN:9780323907279
Published Online:01 September 2021

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