Zoetmulder, R. et al. (2021) Automated final lesion segmentation in posterior circulation acute ischemic stroke using deep learning. Diagnostics, 11(9), 1621. (doi: 10.3390/diagnostics11091621)
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Publisher's URL: https://www.mdpi.com/2075-4418/11/9/1621
Abstract
Final lesion volume (FLV) is a surrogate outcome measure in anterior circulation stroke (ACS). In posterior circulation stroke (PCS), this relation is plausibly understudied due to a lack of methods that automatically quantify FLV. The applicability of deep learning approaches to PCS is limited due to its lower incidence compared to ACS. We evaluated strategies to develop a convolutional neural network (CNN) for PCS lesion segmentation by using image data from both ACS and PCS patients. We included follow-up non-contrast computed tomography scans of 1018 patients with ACS and 107 patients with PCS. To assess whether an ACS lesion segmentation generalizes to PCS, a CNN was trained on ACS data (ACS-CNN). Second, to evaluate the performance of only including PCS patients, a CNN was trained on PCS data. Third, to evaluate the performance when combining the datasets, a CNN was trained on both datasets. Finally, to evaluate the performance of transfer learning, the ACS-CNN was fine-tuned using PCS patients. The transfer learning strategy outperformed the other strategies in volume agreement with an intra-class correlation of 0.88 (95% CI: 0.83–0.92) vs. 0.55 to 0.83 and a lesion detection rate of 87% vs. 41–77 for the other strategies. Hence, transfer learning improved the FLV quantification and detection rate of PCS lesions compared to the other strategies.
Item Type: | Articles |
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Keywords: | Posterior stroke, segmentation, transfer learning, deep learning, CT. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Muir, Professor Keith |
Creator Roles: | |
Authors: | Zoetmulder, R., Konduri, P. R., Obdeijn, I. V., Gavves, E., Išgum, I., Majoie, C. B.L.M., Dippel, D. W. J., Roos, Y. B. W. E. M., Goyal, M., Mitchell, P. J., Campbell, B. C. V., Lopes, D. K., Reimann, G., Jovin, T. G., Saver, J. L., Muir, K. W., White, P., Bracard, S., Chen, B., Brown, S., Schonewille, W. J., Hoeven, E. v. d., Puetz, V., and Marquering, H. A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Diagnostics |
Publisher: | MDPI |
ISSN: | 2075-4418 |
ISSN (Online): | 2075-4418 |
Published Online: | 04 September 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Diagnostics 11(9): 1621 |
Publisher Policy: | Reproduced under a Creative Commons License |
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