The genomics of heart failure: design and rationale of the HERMES consortium

Lumbers, R. T. et al. (2021) The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, (doi: 10.1002/ehf2.13517) (PMID:34480422) (Early Online Publication)

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Abstract

Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome‐wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow‐up following heart failure diagnosis ranged from 2 to 116 months. Forty‐nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low‐frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ford, Professor Ian and Kober, Professor Lars and Sattar, Professor Naveed and Stott J, Professor David and McMurray, Professor John and Cleland, Professor John and Mordi, Dr Ify
Authors: Lumbers, R. T., Shah, S., Lin, H., Czuba, T., Henry, A., Swerdlow, D. I., Mälarstig, A., Andersson, C., Verweij, N., Holmes, M. V., Ärnlöv, J., Svensson, P., Hemingway, H., Sallah, N., Almgren, P., Aragam, K. G., Asselin, G., Backman, J. D., Biggs, M. L., Bloom, H. L., Boersma, E., Brandimarto, J., Brown, M. R., Brunner‐La Rocca, H.‐P., Carey, D. J., Chaffin, M. D., Chasman, D. I., Chazara, O., Chen, X., Chen, X., Chung, J. H., Chutkow, W., Cleland, J. G.F., Cook, J. P., de Denus, S., Dehghan, A., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Engström, G., Esko, T., Fatemifar, G., Felix, S. B., Finan, C., Ford, I., Fougerousse, F., Fouodjio, R., Ghanbari, M., Ghasemi, S., Giedraitis, V., Giulianini, F., Gottdiener, J. S., Gross, S., Guðbjartsson, D. F., Gui, H., Gutmann, R., Haggerty, C. M., van der Harst, P., Hedman, Å. K., Helgadottir, A., Hillege, H., Hyde, C. L., Jacob, J., Jukema, J. W., Kamanu, F., Kardys, I., Kavousi, M., Khaw, K.‐T., Kleber, M. E., Køber, L., Koekemoer, A., Kraus, B., Kuchenbaecker, K., Langenberg, C., Lind, L., Lindgren, C. M., London, B., Lotta, L. A., Lovering, R. C., Luan, J.'a., Magnusson, P., Mahajan, A., Mann, D., Margulies, K. B., Marston, N. A., März, W., McMurray, J. J.V., Melander, O., Melloni, G., Mordi, I. R., Morley, M. P., Morris, A. D., Morris, A. P., Morrison, A. C., Nagle, M. W., Nelson, C. P., Newton‐Cheh, C., Niessner, A., Niiranen, T., Nowak, C., O'Donoghue, M. L., Owens, A. T., Palmer, C. N.A., Paré, G., Perola, M., Perreault, L.‐P. L., Portilla‐Fernandez, E., Psaty, B. M., Rice, K. M., Ridker, P. M., Romaine, S. P.R., Roselli, C., Rotter, J. I., Ruff, C. T., Sabatine, M. S., Salo, P., Salomaa, V., van Setten, J., Shalaby, A. A., Smelser, D. T., Smith, N. L., Stefansson, K., Stender, S., Stott, D. J., Sveinbjörnsson, G., Tammesoo, M.‐L., Tardif, J.‐C., Taylor, K. D., Teder‐Laving, M., Teumer, A., Thorgeirsson, G., Thorsteinsdottir, U., Torp‐Pedersen, C., Trompet, S., Tuckwell, D., Tyl, B., Uitterlinden, A. G., Vaura, F., Veluchamy, A., Visscher, P. M., Völker, U., Voors, A. A., Wang, X., Wareham, N. J., Weeke, P. E., Weiss, R., White, H. D., Wiggins, K. L., Xing, H., Yang, J., Yang, Y., Yerges‐Armstrong, L. M., Yu, B., Zannad, F., Zhao, F., Wilk, J. B., Holm, H., Sattar, N., Lubitz, S. A., Lanfear, D. E., Shah, S., Dunn, M. E., Wells, Q. S., Asselbergs, F. W., Hingorani, A. D., Dubé, M.‐P., Samani, N. J., Lang, C. C., Cappola, T. P., Ellinor, P. T., Vasan, R. S., and Smith, J. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:ESC Heart Failure
Publisher:Wiley
ISSN:2055-5822
ISSN (Online):2055-5822
Published Online:03 September 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in ESC Heart Failure 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science