Autophagy in major human diseases

Klionsky, D. J. et al. (2021) Autophagy in major human diseases. EMBO Journal, 40(19), e108863. (doi: 10.15252/embj.2021108863) (PMID:34459017) (PMCID:PMC8488577)

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Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M.K., Choi, M. E., Chu, C. T., Codogno, P., Colombo, M. I., Cuervo, A. M., Deretic, V., Dikic, I., Elazar, Z., Eskelinen, E.‐L., Fimia, G. M., Gewirtz, D. A., Green, D. R., Hansen, M., Jäättelä, M., Johansen, T., Juhász, G., Karantza, V., Kraft, C., Kroemer, G., Ktistakis, N. T., Kumar, S., Lopez‐Otin, C., Macleod, K. F., Madeo, F., Martinez, J., Meléndez, A., Mizushima, N., Münz, C., Penninger, J. M., Perera, R. M., Piacentini, M., Reggiori, F., Rubinsztein, D. C., Ryan, K. M., Sadoshima, J., Santambrogio, L., Scorrano, L., Simon, H.‐U., Simon, A. K., Simonsen, A., Stolz, A., Tavernarakis, N., Tooze, S. A., Yoshimori, T., Yuan, J., Yue, Z., Zhong, Q., Galluzzi, L., and Pietrocola, F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:EMBO Journal
Publisher:EMBO Press
ISSN:0261-4189
ISSN (Online):1460-2075
Published Online:30 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in EMBO Journal 40(19): e108863
Publisher Policy:Reproduced under a Creative Commons License

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