Transcriptional regulation by the NFAT family in acute myeloid leukaemia

Patterson, S. D., Huang, X. , Jørgensen, H. G. and Michie, A. M. (2021) Transcriptional regulation by the NFAT family in acute myeloid leukaemia. Hemato, 2(3), pp. 556-571. (doi: 10.3390/hemato2030035)

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Abstract

Acute myeloid leukaemia (AML) is a haematological cancer with poor outcomes due to a lack of efficacious targeted therapies. The Nuclear Factor of Activated T Cells (NFAT) family of transcription factors is well characterised as a regulator of the cell cycle and differentiation in the myeloid lineage. Recent evidence has demonstrated that NFAT family members may have roles in regulating AML leukemogenesis and resistance to targeted therapy in myeloid leukaemia. Furthermore, gene expression data from patient samples show that some NFATs are more highly expressed in poorly differentiated AML and after disease relapse, implying that the NFAT family may have roles in specific types of AML. This review outlines the evidence for the role of NFAT in healthy myeloid tissue and explores how NFAT might regulate AML pathogenesis, highlighting the potential to target specific NFAT proteins therapeutically in AML.

Item Type:Articles
Additional Information:This research was funded by The Carnegie Trust for the Universities of Scotland, PhD scholarship number PHD007721.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jorgensen, Dr Heather and Patterson, Shaun and Michie, Dr Alison and Huang, Dr Xu
Creator Roles:
Patterson, S. D.Conceptualization, Software, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review and editing, Visualization
Huang, X.Conceptualization, Resources, Writing – review and editing, Supervision
Jørgensen, H. G.Writing – review and editing, Supervision
Michie, A. M.Writing – review and editing, Supervision
Authors: Patterson, S. D., Huang, X., Jørgensen, H. G., and Michie, A. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Hemato
Publisher:MDPI
ISSN:2673-6357
ISSN (Online):2673-6357
Published Online:27 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Hemato 2(3): 556-571
Publisher Policy:Reproduced under a Creative Commons License

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