Variation in water contact behaviour and risk of Schistosoma mansoni (re)infection among Ugandan school-aged children in an area with persistent high endemicity

Trienekens, S. C. M., Faust, C. L. , Besigye, F., Pickering, L. , Tukahebwa, E. M., Seeley, J. and Lamberton, P. H. L. (2022) Variation in water contact behaviour and risk of Schistosoma mansoni (re)infection among Ugandan school-aged children in an area with persistent high endemicity. Parasites and Vectors, 15, 15. (doi: 10.1186/s13071-021-05121-6) (PMID:34991702) (PMCID:PMC8734346)

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Abstract

Background: Annual mass drug administration with praziquantel has reduced schistosomiasis transmission in some highly endemic areas, but areas with persistent high endemicity have been identified across sub-Saharan Africa, including Uganda. In these areas many children are rapidly reinfected post treatment, while some children remain uninfected or have low-intensity infections. The aim of this mixed-methods study was to better understand variation in water contact locations, behaviours and infection risk in school-aged children within an area with persistent high endemicity to inform additional control efforts. Methods: Data were collected in Bugoto, Mayuge District, Uganda. Two risk groups were identified from a longitudinal cohort, and eight children with no/low-intensity infections and eight children with reinfections were recruited. Individual structured day-long observations with a focus on water contact were conducted over two periods in 2018. In all identified water contact sites, four snail surveys were conducted quarterly over 1 year. All observed Biomphalaria snails were collected, counted and monitored in the laboratory for Schistosoma mansoni cercarial shedding for 3 weeks. Results: Children came into contact with water for a range of purposes, either directly at the water sources or by coming into contact with water collected previously. Although some water contact practices were similar between the risk groups, only children with reinfection were observed fetching water for commercial purposes and swimming in water sources; this latter group of children also came into contact with water at a larger variety and number of sites compared to children with no/low-intensity infection. Households with children with no/low-intensity infections collected rainwater more often. Water contact was observed at 10 sites throughout the study, and a total of 9457 Biomphalaria snails were collected from these sites over four sampling periods. Four lake sites had a significantly higher Biomphalaria choanomphala abundance, and reinfected children came into contact with water at these sites more often than children with no/low-intensity infections. While only six snails shed cercariae, four were from sites only contacted by reinfected children. Conclusions: Children with reinfection have more high-risk water contact behaviours and accessed water sites with higher B. choanomphala abundance, demonstrating that specific water contact behaviours interact with environmental features to explain variation in risk within areas with persistent high endemicity. Targeted behaviour change, vector control and safe water supplies could reduce reinfection in school-aged children in these settings.

Item Type:Articles
Additional Information:Funding: The ethnography and malacology were funded by the Lord Kelvin Adam Smith (LKAS) PhD scholarship, University of Glasgow (https://www.gla.ac.uk/research/lkas/lkasfellowships/) to ST. Malacological and parasitological work was also supported by grants from the University of Glasgow, the Scottish Funding Council and the Global Challenges Research Fund (EP/S51584X/1) and the Wellcome Trust (204820/Z/16/Z) to CLF. Fieldwork was supported by a European Research Council Starting Grant to PHLL (SCHISTO_PERSIST 680088) and the Medical Research Council GCRF to PHLL, LP and JS (MR/P025447/1).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Faust, Christina and Pickering, Dr Lucy and Lamberton, Dr Poppy and Trienekens, Suzan
Authors: Trienekens, S. C. M., Faust, C. L., Besigye, F., Pickering, L., Tukahebwa, E. M., Seeley, J., and Lamberton, P. H. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Social Sciences > School of Social and Political Sciences
Journal Name:Parasites and Vectors
Publisher:BioMed Central
ISSN:1756-3305
ISSN (Online):1756-3305
Published Online:06 January 2022
Copyright Holders:Copyright © The Author(s) 2021
First Published:First published in Parasites and Vectors 15: 15
Publisher Policy:Reproduced under a Creative Commons licence
Data DOI:10.5525/gla.researchdata.1233

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
306188EPSRC-GCRF Global Impact Accelerator Account 2018 UofGJonathan CooperEngineering and Physical Sciences Research Council (EPSRC)EP/S51584X/1Research and Innovation Services
174071Cultural, social and economic influences on ongoing schistosomiasis transmission, despite a decade of mass treatment, and the potential for changePoppy LambertonMedical Research Council (MRC)MR/P025447/1Institute of Biodiversity, Animal Health and Comparative Medicine