Papalazarou, V. and Maddocks, O. D.K. (2021) Supply and demand: cellular nutrient uptake and exchange in cancer. Molecular Cell, 81(18), pp. 3731-3748. (doi: 10.1016/j.molcel.2021.08.026) (PMID:34547236)
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Abstract
Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells have developed multiple strategies to secure the necessary nutrients that fuel their metabolic needs. This is more evident upon disruption of homeostasis in conditions such as cancer, when cells display high proliferation rates in energetically challenging conditions where nutritional sources may be scarce. Here, we summarize the main routes of nutrient acquisition that fuel mammalian cells and their implications in tumorigenesis. We argue that the molecular mechanisms of nutrient acquisition not only tip the balance between nutrient supply and demand but also determine cell behavior upon nutrient limitation and energetic stress and contribute to nutrient partitioning and metabolic coordination between different cell types in inflamed or tumorigenic environments.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Papalazarou, Vasileios and Maddocks, Professor Oliver |
Authors: | Papalazarou, V., and Maddocks, O. D.K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Molecular Cell |
Publisher: | Elsevier (Cell Press) |
ISSN: | 1097-2765 |
ISSN (Online): | 1097-4164 |
Published Online: | 21 September 2021 |
Copyright Holders: | Copyright © 2021 Elsevier Inc. |
First Published: | First published in Molecular Cell 81(18): 3731-3748 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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