Hemostasis and anticoagulants

Wilson, M. R. and Tait, R. C. (2014) Hemostasis and anticoagulants. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 479-496. ISBN 9780123868831 (doi: 10.1016/b978-0-12-386882-4.00023-2)

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The traditional anticoagulants in clinical use for the prevention or treatment of thromboembolic disease are heparin (and its analogs) and warfarin. However, these drugs have major limitations: a narrow therapeutic index; high interindividual variability in a variable dose-response relationship that requires monitoring by laboratory testing; and numerous drug–drug interactions. These limitations have provided the impetus not only for pharmacogenomic studies of efficacy and toxicity for warfarin, but also for the development of other antithrombotic agents that target discrete factors in the coagulation cascade. In this chapter, we outline the coagulation cascade and describe the pharmacology of traditional and novel anticoagulants.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Wilson, Dr Matthew and Tait, Dr Robert
Authors: Wilson, M. R., and Tait, R. C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Publisher:Academic Press
Published Online:02 May 2014

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