The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: design and multicenter pilot study

Weaver, N. A. et al. (2019) The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: design and multicenter pilot study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11(1), pp. 310-326. (doi: 10.1016/j.dadm.2019.02.007) (PMID:31011619) (PMCID:PMC6465616)

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Abstract

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Makin, Dr Stephen and Hamilton, Dr Olivia
Authors: Weaver, N. A., Zhao, L., Biesbroek, J. M., Kuijf, H. J., Aben, H. P., Bae, H.‐J., Caballero, M. Á.A., Chappell, F. M., Chen, C. P.L.H., Dichgans, M., Duering, M., Georgakis, M. K., Giessen, R. S., Gyanwali, B., Hamilton, O. K.L., Hilal, S., Hofe, E. M., Kort, P. L.M., Koudstaal, P. J., Lam, B. Y.K., Lim, J.‐S., Makin, S. D.J., Mok, V. C.T., Shi, L., Valdés Hernández, M. C., Venketasubramanian, N., Wardlaw, J. M., Wollenweber, F. A., Wong, A., Xin, X., DeCarli, C., Fletcher, E.A., Maillard, P., Barnes, J., Sudre, C.H., Schott, J.M., Ikram, M.A., Papma, J.M., Steketee, R.M.E., Vernooij, M.W., Bordet, R., Lopes, R., Huang, C.‐W., Frayne, R., McCreary, C.R., Smith, E.E., Backes, W., Köhler, S., Oostenbrugge, R.J., Staals, J., Verhey, F., Cheng, C.Y., Kalaria, R.N., Werring, D., Hsu, J.L., Huang, K.‐L., Grond, J., Jukema, J.W., Mast, R.C., Nijboer, T.C.W., Yu, K.‐H., Schmidt, R., Pirpamer, L., MacIntosh, B.J., Robertson, A.D., Leeuw, F.‐E., Tuladhar, A.M., Chaturvedi, N., Tillin, T., Brodaty, H., Sachdev, P., Barkhof, F., Flier, W.M., Kappelle, L.J., and Biessels, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Publisher:Elsevier
ISSN:2352-8729
ISSN (Online):2352-8729
Published Online:12 April 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 11(1): 310-326
Publisher Policy:Reproduced under a Creative Commons License

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