Weaver, N. A. et al. (2019) The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: design and multicenter pilot study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11(1), pp. 310-326. (doi: 10.1016/j.dadm.2019.02.007) (PMID:31011619) (PMCID:PMC6465616)
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Abstract
Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Makin, Dr Stephen and Hamilton, Dr Olivia |
Authors: | Weaver, N. A., Zhao, L., Biesbroek, J. M., Kuijf, H. J., Aben, H. P., Bae, H.‐J., Caballero, M. Á.A., Chappell, F. M., Chen, C. P.L.H., Dichgans, M., Duering, M., Georgakis, M. K., Giessen, R. S., Gyanwali, B., Hamilton, O. K.L., Hilal, S., Hofe, E. M., Kort, P. L.M., Koudstaal, P. J., Lam, B. Y.K., Lim, J.‐S., Makin, S. D.J., Mok, V. C.T., Shi, L., Valdés Hernández, M. C., Venketasubramanian, N., Wardlaw, J. M., Wollenweber, F. A., Wong, A., Xin, X., DeCarli, C., Fletcher, E.A., Maillard, P., Barnes, J., Sudre, C.H., Schott, J.M., Ikram, M.A., Papma, J.M., Steketee, R.M.E., Vernooij, M.W., Bordet, R., Lopes, R., Huang, C.‐W., Frayne, R., McCreary, C.R., Smith, E.E., Backes, W., Köhler, S., Oostenbrugge, R.J., Staals, J., Verhey, F., Cheng, C.Y., Kalaria, R.N., Werring, D., Hsu, J.L., Huang, K.‐L., Grond, J., Jukema, J.W., Mast, R.C., Nijboer, T.C.W., Yu, K.‐H., Schmidt, R., Pirpamer, L., MacIntosh, B.J., Robertson, A.D., Leeuw, F.‐E., Tuladhar, A.M., Chaturvedi, N., Tillin, T., Brodaty, H., Sachdev, P., Barkhof, F., Flier, W.M., Kappelle, L.J., and Biessels, G. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU |
Journal Name: | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Publisher: | Elsevier |
ISSN: | 2352-8729 |
ISSN (Online): | 2352-8729 |
Published Online: | 12 April 2019 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 11(1): 310-326 |
Publisher Policy: | Reproduced under a Creative Commons License |
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