Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

Clancy, U. et al. (2021) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. European Stroke Journal, 6(1), pp. 81-88. (doi: 10.1177/2396987320929617) (PMID:33817338) (PMCID:PMC7995323)

Abstract

Background: Cerebral small vessel disease is a major cause of dementia and stroke, visible on brain magnetic resonance imaging. Recent data suggest that small vessel disease lesions may be dynamic, damage extends into normal-appearing brain and microvascular dysfunctions include abnormal blood–brain barrier leakage, vasoreactivity and pulsatility, but much remains unknown regarding underlying pathophysiology, symptoms, clinical features and risk factors of small vessel disease. Patients and Methods: The Mild Stroke Study 3 is a prospective observational cohort study to identify risk factors for and clinical implications of small vessel disease progression and regression among up to 300 adults with non-disabling stroke. We perform detailed serial clinical, cognitive, lifestyle, physiological, retinal and brain magnetic resonance imaging assessments over one year; we assess cerebrovascular reactivity, blood flow, pulsatility and blood–brain barrier leakage on magnetic resonance imaging at baseline; we follow up to four years by post and phone. The study is registered ISRCTN 12113543. Summary: Factors which influence direction and rate of change of small vessel disease lesions are poorly understood. We investigate the role of small vessel dysfunction using advanced serial neuroimaging in a deeply phenotyped cohort to increase understanding of the natural history of small vessel disease, identify those at highest risk of early disease progression or regression and uncover novel targets for small vessel disease prevention and therapy.

• Item Type: Articles
• Additional Information: This work is supported by: the UK Dementia Research Institute which receives its funding from DRI Ltd, funded by the UK MRC, Alzheimer’s Society and Alzheimer’s Research UK; the Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease (16 CVD 05); Stroke Association ‘Small Vessel Disease-Spotlight on Symptoms (SVD-SOS)’(SAPG 19\100068; The Row Fogo Charitable Trust Centre for Research into Aging and the Brain; Stroke Association Garfield Weston Foundation Senior Clinical Lectureship (FND) (TSALECT 2015/04); NHS Research Scotland (FND); Stroke Association Post-Doctoral Fellowship (SW) (SAPDF 18/100026); British Heart Foundation Edinburgh Centre for Research Excellence (RE/18/5/34216); NHS Lothian Research and Development Office (MJT); European Union Horizon 2020, PHC-03–15, project No666881, ‘SVDs@Target’ (MS,GB); Chief Scientist Office of Scotland Clinical Academic Fellowship (UC) (CAF/18/08); Stroke Association Princess Margaret Research Development Fellowship (UC) (2018); Medical Research Scotland studentship (AM) (PhD-1165–2017); College of Medicine and Veterinary Medicine, University of Edinburgh scholarship, as part of the Wellcome-funded Translational Neuroscience PhD programme (OH); MRC Doctoral Training Programme in Precision Medicine (CM) (MR/R01566X/1). The Research MR scanners are supported by the Scottish Funding Council through the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration; the 3T scanner is funded by the Wellcome Trust (104916/Z/14/Z), Dunhill Trust (R380R/1114), Edinburgh and Lothians Health Foundation (2012/17), Muir Maxwell Research Fund and the University of Edinburgh.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hamilton, Dr Olivia
• Authors: Clancy, U., Garcia, D. J., Stringer, M. S., Thrippleton, M. J., Valdés-Hernández, M. C., Wiseman, S., Hamilton, O. K.L., Chappell, F. M., Brown, R., Blair, G. W., Hewins, W., Sleight, E., Ballerini, L., Bastin, M. E., Maniega, S. M., MacGillivray, T., Hetherington, K., Hamid, C., Arteaga, C., Morgan, A. G., Manning, C., Backhouse, E., Hamilton, I., Job, D., Marshall, I., Doubal, F. N., and Wardlaw, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
• Journal Name: European Stroke Journal
• Publisher: SAGE Publications
• ISSN: 2396-9873
• ISSN (Online): 2396-9881
• Published Online: 05 June 2020
• Copyright Holders: Copyright © 2020 European Stroke Organisation
• First Published: First published in European Stroke Journal 6(1) 81-88
• Publisher Policy: Reproduced under a Creative Commons License