Iselin, L., Palmalux, N., Kamel, W. , Simmonds, P., Mohammed, S. and Castello, A. (2022) Uncovering viral RNA-host cell interactions on a proteome-wide scale. Trends in Biochemical Sciences, 47(1), pp. 23-38. (doi: 10.1016/j.tibs.2021.08.002) (PMID:34509361)
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Abstract
RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host–virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vRNPs). Applied to 11 viruses so far, these approaches have revealed hundreds of cellular RBPs that interact with viral (v)RNA in infected cells. However, consistency across methods is limited, raising questions about methodological considerations when designing and interpreting these studies. Here, we discuss these caveats and, through comparing available vRNA interactomes, describe RBPs that are consistently identified as vRNP components and outline their potential roles in infection. In summary, these novel approaches have uncovered a new universe of host–virus interactions holding great therapeutic potential.
| Item Type: | Articles |
|---|---|
| Additional Information: | A.C. is supported by Medical Research Council (MRC) Career Development Award MR/L019434/1 and MRC grants MR/R021562/1, MC_UU_12014/10, and MC_UU_12014/12. L.I. is funded by BBSRC DTP scholarship number BB/M011224/1. N.P. is funded by the MRC CVR PhD programme. W.K. is funded by the European Union’s Horizon 2020 research and innovation programme under Marie-Skłodowska-Curie actions (grant 842067). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Palmalux, Natasha and Castello, Professor Alfredo and Iselin, Louisa and Kamel, Dr Wael |
| Authors: | Iselin, L., Palmalux, N., Kamel, W., Simmonds, P., Mohammed, S., and Castello, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Trends in Biochemical Sciences |
| Publisher: | Elsevier (Cell Press) |
| ISSN: | 0968-0004 |
| ISSN (Online): | 1362-4326 |
| Published Online: | 09 September 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Trends in Biochemical Sciences 47(1): 23-38 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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