Mechanisms of sodium-mediated injury in cardiovascular disease: old play, new scripts

Rossitto, G. and Delles, C. (2021) Mechanisms of sodium-mediated injury in cardiovascular disease: old play, new scripts. FEBS Journal, (doi: 10.1111/febs.16155) (PMID:34355504) (Early Online Publication)

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Abstract

There is a strong association between salt intake and cardiovascular diseases, particularly hypertension, on the population level. The mechanisms that explain this association remain incompletely understood and appear to extend beyond blood pressure. In this review we describe some of the "novel" roles of Na+ in cardiovascular health and disease: energetic implications of sodium handling in the kidneys; local accumulation in tissue; fluid dynamics and the role of the microvasculature, with particular focus on the lymphatic system. We describe the interplay between these factors that involves body composition, metabolic signatures, inflammation and composition of the extracellular and intracellular milieus.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Rossitto, Dr Giacomo and Delles, Professor Christian
Authors: Rossitto, G., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:FEBS Journal
Publisher:Wiley
ISSN:1742-464X
ISSN (Online):1742-4658
Published Online:05 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in FEBS Journal 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science