MICAL2 fine-tunes Arp2/3 for actin branching

Olson, M. F. and Machesky, L. M. (2021) MICAL2 fine-tunes Arp2/3 for actin branching. Journal of Cell Biology, 220(8), e202106176. (doi: 10.1083/jcb.202106176) (PMID:34264264)

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The ARP2/3 complex promotes branched actin networks, but the importance of specific subunit isoforms is unclear. In this issue, Galloni, Carra, et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202102043) show that MICAL2 mediates methionine oxidation of ARP3B, thus destabilizing ARP2/3 complexes and leading to disassembly of branched actin filaments.

Item Type:Articles
Additional Information:M.F. Olson is funded by grants from the Canadian Institutes of Health Research (PJT-169125), Natural Sciences and Engineering Research Council of Canada (RGPIN-2020-05388) and Canada Research Chairs Program (950-231665). L.M. Machesky is funded by Cancer Research UK core grant A17196.
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura and Olson, Professor Michael
Authors: Olson, M. F., and Machesky, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Cell Biology
Publisher:Rockefeller University Press
ISSN (Online):1540-8140
Published Online:15 July 2021
Copyright Holders:Copyright © 2021 Olson and Machesky
First Published:First published in Journal of Cell Biology 220(8): e202106176
Publisher Policy:Reproduced under a Creative Commons License

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