The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19

McGovern, J., Al-Azzawi, Y., Kemp, O., Moffitt, P., Richards, C., Dolan, R. D. , Laird, B. J., McMillan, D. C. and Maguire, D. (2022) The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19. Journal of Translational Medicine, 20, 98. (doi: 10.1186/s12967-022-03300-2) (PMID:35189900) (PMCID:PMC8860274)

[img] Text
247257.pdf - Published Version
Available under License Creative Commons Attribution.

704kB

Abstract

Background: Frailty, determined by the Canadian Study of Health and Aging-Clinical Frailty Scale (CFS), is strongly associated with clinical outcomes including mortality in patients with COVID-19. However, the relationship between frailty and other recognised prognostic factors including age, nutritional status, obesity, sarcopenia and systemic inflammation is poorly understood. Therefore, the aim of this study was to examine the relationship between frailty and other prognostic domains, in patients admitted with COVID-19. Methods: Patients who presented to our institutions between 1st April 2020–6th July 2020 with confirmed COVID-19 were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, CFS admission assessment, Malnutrition Universal Screening Tool (MUST), CT-BC measurements and markers of systemic inflammation. Results: 106 patients met the study inclusion criteria. The majority of patients were aged ≥ 70 years (67%), male (53%) and frail (scoring > 3 on the CFS, 72%). The majority of patients were not malnourished (MUST 0, 58%), had ≥ 1 co-morbidity (87%), were sarcopenic (low SMI, 80%) and had systemic inflammation (mGPS ≥ 1, 81%, NLR > 5, 55%). On multivariate binary logistics regression analysis, age (p < 0.01), COPD (p < 0.05) and NLR (p < 0.05) remained independently associated with frailty. On univariate binary logistics regression, NLR (p < 0.05) was significantly associated with 30-day mortality. Conclusion: Frailty was independently associated with age, co-morbidity, and systemic inflammation. The basis of the relationship between frailty and clinical outcomes in COVID-19 requires further study. Trial registration Registered with clinicaltrials.gov (NCT04484545).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maguire, Donogh and Dolan, Dr Ross and McMillan, Professor Donald and Laird, Dr Barry and McGovern, Mr Josh
Authors: McGovern, J., Al-Azzawi, Y., Kemp, O., Moffitt, P., Richards, C., Dolan, R. D., Laird, B. J., McMillan, D. C., and Maguire, D.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Translational Medicine
Publisher:BioMed Central
ISSN:1479-5876
ISSN (Online):1479-5876
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Translational Medicine 20: 98
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record