Photoluminescent nanoparticles for chemical and biological analysis and imaging

Algar, W. R. et al. (2021) Photoluminescent nanoparticles for chemical and biological analysis and imaging. Chemical Reviews, 121(15), pp. 9243-9358. (doi: 10.1021/acs.chemrev.0c01176) (PMID:34282906)

Abstract

Research related to the development and application of luminescent nanoparticles (LNPs) for chemical and biological analysis and imaging is flourishing. Novel materials and new applications continue to be reported after two decades of research. This review provides a comprehensive and heuristic overview of this field. It is targeted to both newcomers and experts who are interested in a critical assessment of LNP materials, their properties, strengths and weaknesses, and prospective applications. Numerous LNP materials are cataloged by fundamental descriptions of their chemical identities and physical morphology, quantitative photoluminescence (PL) properties, PL mechanisms, and surface chemistry. These materials include various semiconductor quantum dots, carbon nanotubes, graphene derivatives, carbon dots, nanodiamonds, luminescent metal nanoclusters, lanthanide-doped upconversion nanoparticles and downshifting nanoparticles, triplet–triplet annihilation nanoparticles, persistent-luminescence nanoparticles, conjugated polymer nanoparticles and semiconducting polymer dots, multi-nanoparticle assemblies, and doped and labeled nanoparticles, including but not limited to those based on polymers and silica. As an exercise in the critical assessment of LNP properties, these materials are ranked by several application-related functional criteria. Additional sections highlight recent examples of advances in chemical and biological analysis, point-of-care diagnostics, and cellular, tissue, and in vivo imaging and theranostics. These examples are drawn from the recent literature and organized by both LNP material and the particular properties that are leveraged to an advantage. Finally, a perspective on what comes next for the field is offered.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Peveler, Dr William
• Authors: Algar, W. R., Massey, M., Rees, K., Higgins, R., Krause, K. D., Darwish, G. H., Peveler, W. J., Xiao, Z., Tsai, H.-Y., Gupta, R., Lix, K., Tran, M. V., and Kim, H.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Chemical Reviews
• Publisher: American Chemical Society
• ISSN: 0009-2665
• ISSN (Online): 1520-6890
• Published Online: 20 July 2021
• Copyright Holders: Copyright © 2021 American Chemical Society
• First Published: First published in Chemical Reviews 121(15): 9243-9358
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher