Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn

Gradwell, M. A. et al. (2022) Diversity of inhibitory and excitatory parvalbumin interneuron circuits in the dorsal horn. Pain, 163(3), e432-e452. (doi: 10.1097/j.pain.0000000000002422) (PMID:34326298) (PMCID:PMC8832545)

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Abstract

Parvalbumin-expressing interneurons (PVINs) in the spinal dorsal horn are found primarily in laminae II inner and III. Inhibitory PVINs (iPVINs) play an important role in segregating innocuous tactile input from pain-processing circuits through presynaptic inhibition of myelinated low-threshold mechanoreceptors and postsynaptic inhibition of distinct spinal circuits. By comparison, relatively little is known of the role of excitatory PVINs (ePVINs) in sensory processing. Here we use neuroanatomical and optogenetic approaches to show that ePVINs comprise a larger proportion of the PVIN population than previously reported, and that both ePVIN and iPVIN populations form synaptic connections amongst (and between) themselves. We find that these cells contribute to neuronal networks that influence activity within several functionally distinct circuits, and that aberrant activity of ePVINs under pathological conditions is well placed to contribute to the development of mechanical hypersensitivity.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Boyle, Dr Kieran and Hughes, Dr David I and Bell, Mr Andrew and Dickie, Dr Allen
Authors: Gradwell, M. A., Boyle, K. A., Browne, T. J., Bell, A. M., Leonardo, J., Peralta Reyes, F. S., Dickie, A. C., Smith, K. M., Callister, R. J., Dayas, C. V., Hughes, D. I., and Graham, B. A.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Pain
Publisher:Lippincott, Williams and Wilkins
ISSN:0304-3959
ISSN (Online):1872-6623
Published Online:28 July 2021
Copyright Holders:Copyright © 2021 International Association for the Study of Pain
First Published:First published in Pain 163(3): e432-e452
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
174050Determining the role of calretinin-RorB spinal interneurons in modulating mechanical painDavid I HughesBiotechnology and Biological Sciences Research Council (BBSRC)BB/P007996/1Institute of Neuroscience & Psychology