Transplantation of kidneys after normothermic perfusion: a single center experience

Pearson, R., Geddes, C., Mark, P. , Clancy, M. and Asher, J. (2021) Transplantation of kidneys after normothermic perfusion: a single center experience. Clinical Transplantation, 35(10), e14431. (doi: 10.1111/ctr.14431) (PMID:34288129)

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Abstract

Background: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability.1,2 NRP may also improve outcomes in kidney transplantation.We present our single center experience of outcomes in imported kidneys following NRP. Methods: Data was obtained from a prospectively maintained database between December 2012 and September 2018. Primary endpoints were incidence of delayed graft function (DGF) and estimated glomerular filtration rate (eGFR). Results: Six-hundred and thirty-two decease donor kidneys were transplanted, 229 from DCD donors, 29 of which had NRP. The DGF rate was lower for NRP versus DCD (six of 29, 20.7% vs. 70 of 200, 35.0%) with reduced duration of DGF. Multivariate analysis demonstrated transplant type to be a statistically significant independent predictor of eGFR at 7 and 14 days. Early transplant function in NRP kidneys was comparable to DBD. There were no graft losses within 30 days in the NRP group. One-year graft loss rate was 3.4% for NRP and 6.0% for standard DCD. Conclusion: This data suggests NRP is safe, and reduces rates of DGF and improves early renal transplant function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Clancy, Mr Marc and Mark, Professor Patrick and Geddes, Dr Colin and Pearson, Robert
Authors: Pearson, R., Geddes, C., Mark, P., Clancy, M., and Asher, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Clinical Transplantation
Publisher:Wiley
ISSN:0902-0063
ISSN (Online):1399-0012
Published Online:19 July 2021
Copyright Holders:Copyright © 2021 John Wiley and Sons A/S
First Published:First published in Clinical Transplantation 35(10): e14431
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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