Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review

Johnstone, M. S., Lynch, G., Park, J. , McSorley, S. and Edwards, J. (2021) Novel methods of risk stratifying patients for metachronous, pre-malignant colorectal polyps: a systematic review. Critical Reviews in Oncology/Haematology, 164, 103421. (doi: 10.1016/j.critrevonc.2021.103421) (PMID:34246774)

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Abstract

Introduction: Despite conventional measures of future polyp risk (histology, dysplasia, size, number), surveillance places a burden on patients and colonoscopy services. We aimed to review novel risk stratification techniques. Methods: A systematic literature review was performed for studies using genomics, transcriptomics, IHC or microbiome as markers of metachronous polyp risk. Results: 4165 papers underwent title, 303 abstract and 215 full paper review. 25 papers were included. 49 mutations/ SNPs/ haplotypes in 23 genes/ chromosomal regions (KRAS, APC, EGFR, COX1/2, IL23R, DRD2, CYP2C9/24A1/7A1, UGT1A6, ODC, ALOX12/15, PGDH, SRC, IGSF5, KCNS3, EPHB1/ KY, FAM188b, 3p24.1, 9q33.2, 13q33.2) correlated with metachronous adenoma / advanced adenoma risk. Expression levels of 6 proteins correlated with metachronous adenoma (p53, β-catenin, COX2, Adnab-9, ALDH1A1) or sessile serrated polyp (ANXA10) risk. Conclusion: Although genomic and IHC markers correlated with metachronous polyp risk, it seems likely that a panel of novel markers will be required to refine this risk.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Park, Mr James and Johnstone, Mark and Lynch, Dr Gerard and Edwards, Professor Joanne and McSorley, Dr Stephen
Authors: Johnstone, M. S., Lynch, G., Park, J., McSorley, S., and Edwards, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Critical Reviews in Oncology/Haematology
Publisher:Elsevier
ISSN:1040-8428
ISSN (Online):1879-0461
Published Online:09 July 2021
Copyright Holders:Copyright © 2021 Elsevier B.V.
First Published:First published in Critical Reviews in Oncology/Haematology 164: 103421
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
309176Integrated Technologies for Improved Polyp Surveillance (INCISE)Joanne EdwardsInnovate UK (INNOVATE)105858CS - Experimental Therapeutics