Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study

Anderson, J. J. et al. (2021) Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study. Journal of Thrombosis and Haemostasis, 19(10), pp. 2533-2538. (doi: 10.1111/jth.15452) (PMID:34242477) (PMCID:PMC8420476)

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Abstract

Background: Venous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of venous thromboembolism. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19. Objectives: To investigate possible association between VTE and COVID-19 severity, independent of other risk factors. Methods: Cohort study of UK Biobank participants recruited between 2006-2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19 related hospital admissions and COVID-19 deaths. The risk of COVID-19 hospitalisation or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for socio-demographic, lifestyle and comorbid covariates. Results: After adjustment for socio-demographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with non-fatal community (RR 1.61, 95% CI 1.02-2.54, p=0.039), non-fatal hospitalised (RR 1.52, 95% CI 1.06-2.17, p=0.024) and severe (hospitalised or fatal) (RR 1.40, 95% CI 1.04-1.89, p=0.025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p=0.009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p=0.786). Conclusion: Our findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.

Item Type:Articles
Additional Information:SVK is funded from a NRS Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_00022/2) and the Scottish Government Chief Scientist Office (SPHSU17). CLN is funded by the Medical Research Council (MR/R024774/1). ED is funded by the Medical Research Council (MC_UU_12017/13) and the Scottish Government Chief Scientist Office (SPHSU13). CB and NS are supported by the British Heart Foundation (RE/18/6134217).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hastie, Dr Claire and Demou, Dr Evangelia and Ho, Dr Frederick and Katikireddi, Professor Vittal and Mackay, Professor Daniel and Welsh, Dr Paul and Niedzwiedz, Dr Claire and Celis, Dr Carlos and Gray, Professor Stuart and Pell, Professor Jill and Sattar, Professor Naveed and Lyall, Dr Donald and Gill, Professor Jason and Anderson, Dr Jana and Berry, Professor Colin and Iliodromiti, Dr Stamatina and Cleland, Professor John and Pellicori, Dr Pierpaolo
Authors: Anderson, J. J., Ho, F. K., Niedzwiedz, C. L., Katikireddi, V., Celis-Morales, C., Iliodromiti, S., Welsh, P., Pellicori, P., Demou, E., Hastie, C. E., Lyall, D. M., Gray, S. R., Forbes, J. F., Gill, J. M.R., Mackay, D. F., Berry, C., Cleland, J. G.F., Sattar, N., and Pell, J. P.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Thrombosis and Haemostasis
Publisher:Wiley
ISSN:1538-7933
ISSN (Online):1538-7836
Published Online:09 July 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Journal of Thrombosis and Haemostasis 19(10): 2533-2538
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
Inequalities in healthMedical Research Council (MRC)MC_UU_00022/2HW - MRC/CSO Social and Public Health Sciences Unit
Chief Scientist Office (CSO)SPHSU17
172690Understanding the impacts of welfare policy on health: A novel data linkage studySrinivasa KatikireddiOffice of the Chief Scientific Adviser (CSO)SCAF/15/02HW - Public Health