COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Abdukahil, S. A. et al. (2021) COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study. Infection, 49(5), pp. 889-905. (doi: 10.1007/s15010-021-01599-5) (PMID:34170486) (PMCID:PMC8231091)

[img] Text
245573.pdf - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.

Item Type:Articles
Additional Information:This work was supported by the Department for International Development and Wellcome Trust [215091/Z/18/Z]; the Bill and Melinda Gates Foundation [OPP1209135]. Country-specific support was provided by the Canadian Institutes of Health Research Coronavirus Rapid Research Funding Opportunity [OV2170359]; the Health Research Board Ireland [CTN Award 2014-012]; National Institute for Health Research (NIHR) [award CO-CIN-01]; the Medical Research Council (MRC) [grant MC_PC_19059]; the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford [award 200907]; NIHR HPRU in Respiratory Infections at Imperial College London with PHE [award 200927]; Liverpool Experimental Cancer Medicine Centre [grant reference C18616/A25153]; NIHR Biomedical Research Centre at Imperial College London [IS-BRC-1215-20013]; EU Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE) [FP7 project 602525]; National Institutes of Health (NIH) [UL1TR002240]; and NIHR Clinical Research Network infrastructure support.
Keywords:COVID-19, SARS-CoV-2, symptoms, diagnosis, case definition.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Scott, Dr Janet
Authors: Abdukahil, S. A., Abe, R., Abel, L., Absil, L., Acker, A., Adachi, S., Adam, E., Adrião, D., Ainscough, K., Hssain, A. A., Tamlihat, Y. A., Akimoto, T., Al-Dabbous, T., Al-Fares, A., Al Qasim, E., Alalqam, R., Alex, B., Alexandre, K., Alfoudri, H., Alidjnou, K. E., Aliudin, J., Allavena, C., Allou, N., Alves, J., Alves, R., Amaral, M., Ammerlaan, H., Ampaw, P., Andini, R., Andrejak, C., Angheben, A., Angoulvant, F., Ansart, S., Antonelli, M., De Brito, C. A. A., Arabi, Y., Aragao, I., Arcadipane, A., Arenz, L., Arlet, J.-B., Arnold-Day, C., Arora, L., Artaud-Macari, E., Asensio, A., Assie, J. B., Atique, A., Auchabie, J., Aumaitre, H., Azemar, L., Azoulay, C., Bach, B., Bachelet, D., Baillie, J. K., Bak, E., Bakakos, A., Banisadr, F., Barbalho, R., Barclay, W. S., Barnikel, M., Barrelet, A., Barrigoto, C., Basmaci, R., Rincon, D. F. B., Bedossa, A., Behilill, S., Beljantsev, A., Bellemare, D., Beltrame, A., Beluze, M., Benech, N., Benkerrou, D., Bennett, S., Bento, L., Berdal, J.-E., Bergeaud, D., Bertolino, L., Bessis, S., Bevilcaqua, S., Bhavsar, K., Humaid, F. B., Bissuel, F., Biston, P., Bitker, L., Blanco-Schweizer, P., Blot, M., Boccia, F., Bogaert, D., Bompart, F., Booth, G., Borges, D., Borie, R., Bos, J., Bosse, H. M., Botelho-Nevers, E., Bouadma, L., Bouchaud, O., Bouchez, S., Bouhmani, D., Bouhour, D., Bouiller, K., Bouillet, L., Bouisse, C., Boureau, A.-S., Bouscambert, M., Bouziotis, J., Boxma, B., Boyer-Besseyre, M., Boylan, M., Braga, C., Brandenburger, T., Brazzi, L., Breen, D., Breen, P., Brickell, K., Brozzi, N., Buchtele, N., Buesaquillo, C., Bugaeva, P., Buisson, M., Burhan, E., Bustos, I. G., Butnaru, D., Cárcel, S., Cabie, A., Cabral, S., Caceres, E., Callahan, M., Calligy, K., Calvache, J. A., Camões, J., Campana, V., Campbell, P., Canepa, C., Cantero, M., Caraux-Paz, P., Cardoso, F., Cardoso, F., Cardoso, S., Carelli, S., Carlier, N., Carney, G., Carpenter, C., Carret, M.-C., Carrier, F. M., Carson, G., Casanova, M.-L., Cascão, M., Casimiro, J., Cassandra, B., Castañeda, S., Castanheira, N., Castor-Alexandre, G., Castrillón, H., Castro, I., Catarino, A., Catherine, F.-X., Cavalin, R., Cavalli, G. G., Cavayas, A., Ceccato, A., Cervantes-Gonzalez, M., Chair, A., Chakveatze, C., Chan, A., Chand, M., Chas, J., Chassin, C., Chen, A., Chen, Y.-S., Cheng, M. P., Cheret, A., Chiarabini, T., Chica, J., Chirouze, C., Chiumello, D., Cho, H. J., Cho, S. M., Cholley, B., Cidade, J. P., Herreros, J. M. C., Citarella, B. W., Ciullo, A., Clarke, J., Clohisey, S., Codan, C., Cody, C., Coelho, A., Colin, G., Collins, M., Colombo, S. M., Combs, P., Connelly, J. P., Connor, M., Conrad, A., Contreras, S., Cooke, G. S., Copland, M., Cordel, H., Corley, A., Cormican, S., Cornelis, S., Corpuz, A. J., Corvaisier, G., Couffignal, C., Couffin-Cadiergues, S., Courtois, R., D’Orleans, C. C., Croonen, S., Crowl, G., Crump, J., Cruz, C., Csete, M., Cucino, A., Cullen, C., Cummings, M., Curley, G., Curlier, E., Custodio, P., D’Aragon, F., Da Silva Filipe, A., Da Silveira, C., D’Ortenzio, E., Dabaliz, A.-A., Dagens, A. B., Dalton, H., Dalton, J., Daneman, N., Dankwa, E. A., Dantas, J., De Castro, N., De Mendoza, D., De Oliveira França, R. F., De Rosa, R., De Silva, T., De Vries, P., Dean, D., Debray, M.-P., Dechert, W., Deconninck, L., Decours, R., Delacroix, I., Delavigne, K., Deligiannis, I., Dell’amore, A., Delobel, P., Demonchy, E., Denis, E., Deplanque, D., Depuydt, P., Desai, M., Descamps, D., Desvallée, M., Dewayanti, S. R., Diallo, A., Diamantis, S., Dias, A., Diaz, J. J. D., Diaz, R., Didier, K., Diehl, J.-L., Dieperink, W., Dimet, J., Dinot, V., Diouf, A., Dishon, Y., Djossou, F., Docherty, A. B., Dong, A., Donnelly, C. A., Donnelly, M., Donohue, C., Dorival, C., Douglas, J. J., Douma, R., Dournon, N., Downer, T., Downing, M., Drake, T., Dubee, V., Dubos, F., Ducancelle, A., Dudman, S., Dunning, J., Mangoni, E. D., Duranti, S., Durham, L., Dussol, B., Duval, X., Dyrhol-Riise, A. M., Eira, C., Vidal, J. E., Sanharawi, M. E., Elapavaluru, S., Elharrar, B., Elkheir, N., Ellerbroek, J., Ellis, R., Eloy, P., Elshazly, T., Enderle, I., Engelmann, I., Enouf, V., Epaulard, O., Esperatti, M., Esperou, H., Esposito-Farese, M., Estevão, J., Etienne, M., Etienne, M., Ettalhaoui, N., Everding, A. G., Evers, M., Fabre, I., Faheem, A., Fahy, A., Fairfield, C. J., Faria, P., Farshait, N., Fatoni, A. Z., Faure, K., Fayed, M., Feely, N., Fernandes, J., Fernandes, M., Fernandes, S., Ferrão, J., Devouge, E. F., Ferraz, M., Ferreira, B., Ferrer-Roca, R., Figueiredo-Mello, C., Flateau, C., Fletcher, T., Florio, L. L., Foley, C., Fomin, V., Fonseca, C. D., Fonseca, T., Fontela, P., Forsyth, S., Foti, G., Fourn, E., Fowler, R., Franch-Llasat, D., Fraser, C., Fraser, J., Freire, M. V., Ribeiro, A. F., Friedrich, C., Fry, S., Fuentes, N., Fukuda, M., Gómez-Junyent, J., Gaborieau, V., Gachet, B., Gaci, R., Gagliardi, M., Gagnard, J.-C., Gagneux-Brunon, A., Gaião, S., Gallagher, P., Curto, E. G., Gamble, C., Garan, A., Garcia-Gallo, E., Garcia, R., Garot, D., Garrait, V., Gault, N., Gavin, A., Gaymard, A., Gebauer, J., Morlaes, L. G., Germano, N., Ghosn, J., Giani, M., Giaquinto, C., Gibson, J., Gigante, T., Gilg, M., Giordano, G., Girvan, M., Gissot, V., Giwangkancana, G., Glikman, D., Glybochko, P., Gnall, E., Goco, G., Goehringer, F., Goepel, S., Goffard, J.-C., Golob, J., Gorenne, I., Goujard, C., Goulenok, T., Grable, M., Grandin, E. W., Granier, P., Grasselli, G., Green, C. A., Greenhalf, W., Greffe, S., Grieco, D. L., Griffee, M., Griffiths, F., Grigoras, I., Groenendijk, A., Lordemann, A. G., Gruner, H., Gu, Y., Guedj, J., Guellec, D., Guerguerian, A.-M., Guerreiro, D., Guery, R., Guillaumot, A., Guilleminault, L., Guimard, T., Haber, D., Hakak, S., Hall, M., Halpin, S., Hamer, A., Hamidfar, R., Hammond, T., Hardwick, H., Harley, K., Harrison, E. M., Harrison, J., Hays, L., Heerman, J., Heggelund, L., Hendry, R., Hennessy, M., Henriquez-Trujillo, A., Hentzien, M., Hernandez-Montfort, J., Hidayah, A., Higgins, D., Higgins, E., Hinton, S., Hipólito-Reis, A., Hiraiwa, H., Hiscox, J. A., Ho, A. Y. W., Hoctin, A., Hoffmann, I., Hoiting, O., Holt, R., Holter, J. C., Horby, P., Horcajada, J. P., Hoshino, K., Hoshino, K., Hough, C. L., Hsu, J. M.-Y., Hulot, J.-S., Ijaz, S., Illes, H.-G., Inácio, H., Dominguez, C. I., Iosifidis, E., Irvine, L., Isgett, S., Isidoro, T., Isnard, M., Itai, J., Ivulich, D., Jaafoura, S., Jabot, J., Jackson, C., Jamieson, N., Jaureguiberry, S., Javidfar, J., Jean-Benoît, Z., Jego, F., Jenum, S., Sotomayor, R. J., GarcÍa, R. N. J., Joseph, C., Joseph, M., Jouvet, P., Jung, H., Kafif, O., Kaguelidou, F., Kali, S., Kalomoiri, S., Kandamby, D. H., Kandel, C., Kant, R., Kartsonaki, C., Kasugai, D., Katz, K., Johal, S. K., Keating, S., Kelly, A., Kelly, S., Kennedy, L., Kennon, K., Kerroumi, Y., Kestelyn, E., Khalid, I., Khalil, A., Khan, C., Khan, I., Kho, M. E., Khoo, S., Kida, Y., Kiiza, P., Kildal, A. B., Kimmoun, A., Kindgen-Milles, D., Kitamura, N., Klenerman, P., Bekken, G. K., Knight, S., Kobbe, R., Vasconcelos, M. K., Korten, V., Kosgei, C., Krawczyk, K., Vecham, P. K., Kumar, D., Kurtzman, E., Kutsogiannis, D., Kyriakoulis, K., L’her, E., Lachatre, M., Lacoste, M., Laffey, J. G., Lagrange, M., Laine, F., Lambert, M., Lamontagne, F., Langelot-Richard, M., Lantang, E. Y., Lanza, M., Laouénan, C., Laribi, S., Lariviere, D., Launay, O., Lavie-Badie, Y., Law, A., Le Bihan, C., Le Bris, C., Le Coustumier, E., Le Falher, G., Le Gac, S., Le Hingrat, Q., Le Maréchal, M., Le Mestre, S., Le Moing, V., Le Nagard, H., Le Turnier, P., León, R., Le, M., Santos, M. L., Leal, E., Lee, J., Lee, S. H., Lee, T., Leeming, G., Lefebvre, B., Lefebvre, L., Lefevre, B., Lellouche, F., Lemaignen, A., Lemee, V., Lemmink, G., Leone, M., Lepiller, Q., Lescure, F.-X., Lesens, O., Lesouhaitier, M., Levy-Marchal, C., Levy, B., Levy, Y., Bassi, G. L., Liang, J., Lim, W. S., Lina, B., Lind, A., Lingas, G., Lion-Daolio, S., Liu, K., Loforte, A., Lolong, N., Lopes, D., Lopez-Colon, D., Loubet, P., Lucet, J. C., Luna, C. M., Lungu, O., Luong, L., Luton, D., Lyons, R., Müller, F., Müller, K. E., Maasikas, O., Macdonald, S., Machado, M., Macheda, G., Sanchez, J. M., Madhok, J., Mahieu, R., Mahy, S., Maier, L. S., Maillet, M., Maitre, T., Malfertheiner, M., Malik, N., Maltez, F., Malvy, D., Mambert, M., Manda, V., Mandei, J. M., Manning, E., Manuel, A., Sant, C. M., Malaque, A., Marino, F., De Araújo Mariz, C., Eid, C. M., Marques, A., Marquis, C., Marsh, B., Marsh, L., Marshall, J., Martelli, C. T., Martin-Blondel, G., Martin-Loeches, I., Martin-Quiros, A., Martin, D.-A., Martin, E., Martinot, M., Rego, C. M., Martins, A., Martins, J., Martucci, G., Marwali, E. M., Jimenez, J. F. M., Maslove, D., Mason, S., Matan, M., Mathieu, D., Mattei, M., Matulevics, R., Maulin, L., Mc Evoy, N., McCarthy, A., McCloskey, C., McConnochie, R., McDermott, S., McDonald, S., McElwee, S., McEvoy, N., McGeer, A., McGuinness, N., McLean, K. A., McNicholas, B., Meaney, E., Mear-Passard, C., Mechlin, M., Mele, F., Menon, K., Mentré, F., Mentzer, A. J., Mercier, N., Merckx, A., Mergler, B., Merson, L., Mesquita, A., Meybeck, A., Meynert, A. M., Meyssonnier, V., Meziane, A., Mezidi, M., Michelanglei, C., Mihnovitš, V., Maldonado, H. M., Mone, M., Moin, A., Molina, D., Molinos, E., Monteiro, A., Montes, C., Montrucchio, G., Moore, S., Moore, S. C., Morales-Cely, L., Moro, L., Tutillo, D. R. M., Motos, A., Mouquet, H., Perrot, C. M., Moyet, J., Mullaert, J., Munblit, D., Murphy, D., Murris, M., Myrodia, D. M., N’guyen, Y., Neant, N., Neb, H., Nekliudov, N. A., Neto, R., Neumann, E., Neves, B., Ng, P. Y., Ng, W. Y., Choileain, O. N., Nichol, A., Nonas, S., Noret, M., Norman, L., Notari, A., Noursadeghi, M., Nowicka, K., Nseir, S., Nunez, J. I., Nyamankolly, E., O’Donnell, M., O’Hearn, K., O’Neil, C., Occhipinti, G., Ogston, T., Ogura, T., Oh, T.-H., Ohshimo, S., Oinam, B. C. S., Oliveira, A. P., Oliveira, J., Olliaro, P., Ong, D. S. Y., Oosthuyzen, W., Openshaw, P. J. M., Orozco-Chamorro, C. M., Orquera, A., Osatnik, J., Ouamara, N., Ouissa, R., Owyang, C., Oziol, E., Póvoas, D., Pagadoy, M., Pages, J., Palacios, M., Palmarini, M., Panarello, G., Panda, P. K., Panigada, M., Pansu, N., Papadopoulos, A., Parra, B., Pasquier, J., Patauner, F., Patrão, L., Paul, C., Paul, M., Paulos, J., Paxton, W. A., Payen, J.-F., Pearse, I., Peek, G. J., Peelman, F., Peiffer-Smadja, N., Peigne, V., Pejkovska, M., Peltan, I. D., Pereira, R., Perez, D., Perpoint, T., Pesenti, A., Petroušová, L., Petrov-Sanchez, V., Peytavin, G., Pharand, S., Piagnerelli, M., Picard, W., Picone, O., Piel-Julian, M., Pierobon, C., Pimentel, C., Piroth, L., Pius, R., Piva, S., Plantier, L., Plotkin, D., Poissy, J., Pokorska-Spiewak, M., Poli, S., Pollakis, G., Popielska, J., Postma, D. F., Povoa, P., Powis, J., Prapa, S., Prebensen, C., Preiser, J.-C., Prestre, V., Price, N., Prinssen, A., Pritchard, M. G., Proença, L., Puéchal, O., Purcell, G., Quesada, L., Quist-Paulsen, E., Quraishi, M., Rätsep, I., Rössler, B., Rabaud, C., Rafiq, M., Ragazzo, G., Rainieri, F., Ramakrishnan, N., Ramanathan, K., Rammaert, B., Rapp, C., Rasmin, M., Rau, C., Rebaudet, S., Redl, S., Reeve, B., Reid, L., Reis, R., Remppis, J., Remy, M., Renk, H., Resende, L., Resseguier, A.-S., Revest, M., Rewa, O., Reyes, L. F., Richardson, D., Richardson, D., Richier, L., Riera, J., Rios, A. L., Rishu, A., Rispal, P., Risso, K., Nuñez, M. A. R., Rizer, N., Roberto, A., Roberts, S., Robertson, D. L., Robineau, O., Roche-Campo, F., Rodari, P., Rodeia, S., Abreu, J. R., Roilides, E., Rojek, A., Romaru, J., Roncon-Albuquerque, R., Roriz, M., Rosa-Calatrava, M., Rose, M., Rosenberger, D., Rossanese, A., Rossignol, B., Rossignol, P., Roy, C., Roze, B., Russell, C. D., Ryckaert, S., Holten, A. R., Choez, X. S., Saba, I., Sadat, M., Saidani, N., Salazar, L., Sales, G., Sallaberry, S., Salvator, H., Sanchez-Miralles, A., Sanchez, O., Sancho-Shimizu, V., Sandhu, G., Sandulescu, O., Santos, M., Sarfo-Mensah, S., Sarton, B., Saviciute, E., Savvidou, P., Scarsbrook, J., Schermer, T., Scherpereel, A., Schneider, M., Schroll, S., Schwameis, M., Scott-Brown, J., Scott, J. T., Sedillot, N., Seitz, T., Semaille, C., Semple, M. G., Senneville, E., Sequeira, F., Sequeira, T., Shadowitz, E., Shamsah, M., Sharma, P., Shaw, C. A., Shaw, V., Shiban, N., Shime, N., Shimizu, H., Shimizu, K., Shrapnel, S., Shum, H. P., Mohammed, N. S., Sigfrid, L., Silva, C., Silva, M. J., Sin, W. C., Skogen, V., Smith, S., Smood, B., Smyth, M., Snacken, M., So, D., Solis, M., Solomon, J., Solomon, T., Somers, E., Sommet, A., Song, M. J., Song, R., Song, T., Sonntagbauer, M., Soum, E., Uva, M. S., Sousa, M., Souza-Dantas, V., Sperry, A., Sriskandan, S., Staudinger, T., Stecher, S.-S., Stienstra, Y., Stiksrud, B., Streinu-Cercel, A., Streinu-Cercel, A., Strudwick, S., Stuart, A., Stuart, D., Sultana, A., Summers, C., Svistunov, M. S. A. A., Syrigos, K., Sztajnbok, J., Szuldrzynski, K., Téoulé, F., Tabrizi, S., Tagherset, L., Talarek, E., Taleb, S., Talsma, J., Le Van, T., Tanaka, H., Tanaka, T., Taniguchi, H., Tardivon, C., Tattevin, P., Taufik, M. A., Tedder, R. S., Teixeira, J., Tellier, M.-C., Terpstra, P., Terrier, O., Terzi, N., Tessier-Grenier, H., Thibault, V., Thiberville, S.-D., Thill, B., Thompson, A. A. R., Thompson, S., Thomson, D., Thomson, E. C., Thuy, D. B., Thwaites, R. S., Timashev, P. S., Timsit, J.-F., Vijayaraghavan, B. K. T., Toki, M., Tonby, K., Santos-Olmo, R. M. T., Torres, A., Torres, M., Trioux, T., Trieu, H. T., Tromeur, C., Trontzas, I., Troost, J., Trouillon, T., Tual, C., Tubiana, S., Tuite, H., Turtle, L. C. W., Twardowski, P., Uchiyama, M., Ullrich, R., Uribe, A., Usman, A., Val-Flores, L., Van De Velde, S., Van Den Berge, M., Van Der Feltz, M., Van Der Vekens, N., Van Der Voort, P., Van Der Werf, S., Van Dyk, M., Van Gulik, L., Van Hattem, J., Van Lelyveld, S., Van Netten, C., Vanel, N., Vanoverschelde, H., Vauchy, C., Veislinger, A., Velazco, J., Ventura, S., Verbon, A., Vieira, C., Villanueva, J. A., Villar, J., Villeneuve, P.-M., Villoldo, A., Van Vinh Chau, N., Visseaux, B., Visser, H., Vuorinen, A., Vuotto, F., Wang, C.-H., Wei, J., Weil, K., Wesselius, S., Wham, M., Whelan, B., White, N., Wiedemann, A., Wille, K., Wils, E.-J., Xynogalas, I., Suen, J. Y., Yacoub, S., Yamazaki, M., Yazdanpanah, Y., Yelnik, C., Yerkovich, S., Yokoyama, T., Yonis, H., Young, P., Yuliarto, S., Zabbe, M., Zacharowski, K., Zahran, M., Zambon, M., Zanella, A., Zawadka, K., Zayyad, H., Zoufaly, A., and Zucman, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Infection
Publisher:Springer
ISSN:0300-8126
ISSN (Online):1439-0973
Published Online:25 June 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Infection 49(5): 889-905
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record