Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21

Fletcher, A. J., James, L. C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

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Abstract

TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity. We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector. We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.

Item Type:Articles
Additional Information:This work, including the efforts of Leo C. James, was funded by Medical Research Council (MRC) (U105181010). This work, including the efforts of Leo C. James, was funded by EC | European Research Council (ERC) (281627-IAI).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fletcher, Dr Adam
Authors: Fletcher, A. J., James, L. C., and Tsai, B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
Publisher:American Society for Microbiology
ISSN:0022-538X
ISSN (Online):1098-5514

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