Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices

Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H. , Mitra, S., Neale, S. L. and Mercer, J. R. (2021) Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices. IEEE Reviews in Biomedical Engineering, (doi: 10.1109/RBME.2021.3110084) (Early Online Publication)

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Abstract

Cardiovascular disease (CVD) is a group of heart and vasculature conditions which are the leading form of mortality worldwide. Blood vessels can become narrowed, restricting blood flow, and drive the majority of hearts attacks and strokes. Surgical interventions are frequently required; including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Despite successful opening of vessels and restoration of blood flow, often in-stent restenosis (ISR) and graft failure can still occur, resulting in subsequent patient morbidity and mortality. A new generation of cardiovascular implants that have sensors and real-time monitoring capabilities are being developed to combat ISR and graft failure. Self-reporting stent/graft technology could enable precision medicine-based healthcare by detecting the earliest features of disease, even before symptoms occur. Bringing an implantable medical device with wireless electronic sensing capabilities to market is complex and often obstructive undertaking. This critical review analyses the obstacles that need to be overcome for self-reporting stents/grafts to be developed and provide a precision-medicine based healthcare for cardiovascular patients. Here we assess the latest research and technological advancement in the field, the current devices and the market potential for their end-user implementation.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hoare, Daniel and Mercer, Dr John and Molloy, Antonia and Neale, Dr Steven and Kirimi, Mr Mahmut and Heidari, Dr Hadi and Mirzai, Mr Nosrat and Mitra, Dr Srinjoy
Authors: Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H., Mitra, S., Neale, S. L., and Mercer, J. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:IEEE Reviews in Biomedical Engineering
Publisher:IEEE
ISSN:1937-3333
ISSN (Online):1941-1189
Published Online:14 September 2021

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
301336Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.John MercerOffice of the Chief Scientific Adviser (CSO)CGA/17/29CAMS - Cardiovascular Science