Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices

Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H. , Mitra, S., Neale, S. L. and Mercer, J. R. (2022) Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices. IEEE Reviews in Biomedical Engineering, 15, pp. 260-272. (doi: 10.1109/RBME.2021.3110084) (PMID:34520361)

Abstract

Cardiovascular disease (CVD) is a group of heart and vasculature conditions which are the leading form of mortality worldwide. Blood vessels can become narrowed, restricting blood flow, and drive the majority of hearts attacks and strokes. Surgical interventions are frequently required; including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Despite successful opening of vessels and restoration of blood flow, often in-stent restenosis (ISR) and graft failure can still occur, resulting in subsequent patient morbidity and mortality. A new generation of cardiovascular implants that have sensors and real-time monitoring capabilities are being developed to combat ISR and graft failure. Self-reporting stent/graft technology could enable precision medicine-based healthcare by detecting the earliest features of disease, even before symptoms occur. Bringing an implantable medical device with wireless electronic sensing capabilities to market is complex and often obstructive undertaking. This critical review analyses the obstacles that need to be overcome for self-reporting stents/grafts to be developed and provide a precision-medicine based healthcare for cardiovascular patients. Here we assess the latest research and technological advancement in the field, the current devices and the market potential for their end-user implementation.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Mercer, Dr John and Molloy, Antonia and Hoare, Dr Daniel and Neale, Professor Steven and Kirimi, Mr Mahmut and Heidari, Professor Hadi and Mirzai, Mr Nosrat and Mitra, Dr Srinjoy
• Authors: Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H., Mitra, S., Neale, S. L., and Mercer, J. R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering; College of Science and Engineering > School of Engineering > Systems Power and Energy
• Journal Name: IEEE Reviews in Biomedical Engineering
• Publisher: IEEE
• ISSN: 1937-3333
• ISSN (Online): 1941-1189
• Published Online: 14 September 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in IEEE Reviews in Biomedical Engineering 15: 260-272
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
190814		BHF centre of excellence	Rhian Touyz	British Heart Foundation (BHF)	RE/13/5/30177	Institute of Cardiovascular & Medical Sciences
301336		Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.	John Mercer	Office of the Chief Scientific Adviser (CSO)	CGA/17/29	CAMS - Cardiovascular Science