Clinical, pathological and immunological aspects of periodontal disease

Kinane, D.F. and Lappin, D.F. (2001) Clinical, pathological and immunological aspects of periodontal disease. Acta Odontologica Scandinavica, 59(3), 154 -160. (doi: 10.1080/000163501750266747)

Abstract

The inflammatory and immune responses during the development and progression of periodontitis are reiewed. Susceptibility to periodontitis may be related to whether plasma cells predominate in the tissues of an individual, or a site, in response to the microbial insult from dental plaque. The tendency for an individual or site to form an extensive plasma cell infiltrate may indicate an inability to defend against periodontopathogenic bacteria and thus a predisposition to periodontitis. Selected pertinent areas of current interest in cellular and humoral immunology are considered within the periodontal context. These topical issues include (a) homing of immune and inflammatory cells to target tissues; (b) the local proliferation and synthetic activity of immune and inflammatory cells; (c) the cytokine profile of the inflammatory and immune cells; and (d) the immunoglobulin subclasses of locally produced antibodies.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lappin, Dr David
• Authors: Kinane, D.F., and Lappin, D.F.
• Subjects: R Medicine > RK Dentistry
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
• Journal Name: Acta Odontologica Scandinavica
• ISSN: 0001-6357