Sex steroids receptors, hypertension and vascular ageing

Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2021) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (Early Online Publication)

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Abstract

Sex hormone receptors are expressed throughout the vasculature and play an important role in the modulation of blood pressure in health and disease. The functions of these receptors may be important in the understanding of sexual dimorphism observed in the pathophysiology of both hypertension and vascular ageing. The interconnectivity of these factors can be exemplified in postmenopausal females, who with age and estrogen deprivation, surpass males with regard to hypertension prevalence, despite experiencing significantly less disease burden in their estrogen replete youth. Estrogen and androgen receptors mediate their actions via direct genomic effects or rapid non-genomic signaling, involving a host of mediators. The expression and subtype composition of these receptors changes through the lifespan in response to age, disease and hormonal exposure. These factors may promote sex steroid receptor-mediated alterations to the Renin–Angiotensin–Aldosterone System (RAAS), and increases in oxidative stress and inflammation, thereby contributing to the development of hypertension and vascular injury with age.

Item Type:Articles
Additional Information:The authors are grateful to the British Heart Foundation (Centre of Research Excellence Award, RE/18/6/34217) for funding our research.
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Casey, Dr Helen and Delles, Professor Christian and Montezano, Dr Augusto and Connelly, Dr Paul and Touyz, Professor Rhian
Authors: Connelly, P. J., Casey, H., Montezano, A. C., Touyz, R. M., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Human Hypertension
Publisher:Springer Nature
ISSN:0950-9240
ISSN (Online):1476-5527
Published Online:06 July 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Journal of Human Hypertension 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science