Connelly, P. J. , Casey, H., Montezano, A. C., Touyz, R. M. and Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36(2), pp. 120-125. (doi: 10.1038/s41371-021-00576-7) (PMID:34230581) (PMCID:PMC8850193)
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Abstract
Sex hormone receptors are expressed throughout the vasculature and play an important role in the modulation of blood pressure in health and disease. The functions of these receptors may be important in the understanding of sexual dimorphism observed in the pathophysiology of both hypertension and vascular ageing. The interconnectivity of these factors can be exemplified in postmenopausal females, who with age and estrogen deprivation, surpass males with regard to hypertension prevalence, despite experiencing significantly less disease burden in their estrogen replete youth. Estrogen and androgen receptors mediate their actions via direct genomic effects or rapid non-genomic signaling, involving a host of mediators. The expression and subtype composition of these receptors changes through the lifespan in response to age, disease and hormonal exposure. These factors may promote sex steroid receptor-mediated alterations to the Renin–Angiotensin–Aldosterone System (RAAS), and increases in oxidative stress and inflammation, thereby contributing to the development of hypertension and vascular injury with age.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Casey, Dr Helen and Delles, Professor Christian and Montezano, Dr Augusto and Connelly, Dr Paul and Touyz, Professor Rhian |
| Authors: | Connelly, P. J., Casey, H., Montezano, A. C., Touyz, R. M., and Delles, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Human Hypertension |
| Publisher: | Springer Nature |
| ISSN: | 0950-9240 |
| ISSN (Online): | 1476-5527 |
| Published Online: | 06 July 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Journal of Human Hypertension 36(2): 120-125 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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