Pathogenesis of musculoskeletal deficits in children and adults with inflammatory bowel disease

Steell, L. , Gray, S. R. , Russell, R. K., MacDonald, J. , Seenan, J. P. , Wong, S. C. and Gaya, D. R. (2021) Pathogenesis of musculoskeletal deficits in children and adults with inflammatory bowel disease. Nutrients, 13(8), 2899. (doi: 10.3390/nu13082899)

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Abstract

Musculoskeletal deficits are among the most commonly reported extra-intestinal manifestations and complications of inflammatory bowel disease (IBD), especially in those with Crohn’s disease. The adverse effects of IBD on bone and muscle are multifactorial, including the direct effects of underlying inflammatory disease processes, nutritional deficits, and therapeutic effects. These factors also indirectly impact bone and muscle by interfering with regulatory pathways. Resultantly, individuals with IBD are at increased risk of osteoporosis and sarcopenia and associated musculoskeletal morbidity. In paediatric IBD, these factors may contribute to suboptimal bone and muscle accrual. This review evaluates the main pathogenic factors associated with musculoskeletal deficits in children and adults with IBD and summarises the current literature and understanding of the musculoskeletal phenotype in these patients.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wong, Dr Jarod and Seenan, Dr John and Steell, Mr Lewis and Gray, Dr Stuart and Russell, Dr Richard and Macdonald, Dr Jonathan and Gaya, Mr Daniel
Creator Roles:
Steell, L.Conceptualization, Writing – original draft, Data curation, Writing – review and editing
Gray, S. R.Writing – review and editing
Russell, R. K.Writing – review and editing
MacDonald, J.Writing – review and editing
Seenan, J. P.Writing – review and editing
Wong, S. C.Conceptualization, Writing – original draft, Data curation, Writing – review and editing, Supervision
Gaya, D. R.Conceptualization, Writing – original draft, Data curation, Writing – review and editing, Supervision
Authors: Steell, L., Gray, S. R., Russell, R. K., MacDonald, J., Seenan, J. P., Wong, S. C., and Gaya, D. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Nutrients
Publisher:MDPI
ISSN:2072-6643
ISSN (Online):2072-6643
Published Online:23 August 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Nutrients 13(8): 2899
Publisher Policy:Reproduced under a Creative Commons License

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