Testing for interactions between APOE and Klotho genotypes on cognitive, dementia, and brain imaging metrics in UK Biobank

Tank, R., Ward, J., Celis-Morales, C. , Smith, D. J. , Flegal, K. E. and Lyall, D. M. (2021) Testing for interactions between APOE and Klotho genotypes on cognitive, dementia, and brain imaging metrics in UK Biobank. Journal of Alzheimer's Disease, 83(1), pp. 51-55. (doi: 10.3233/JAD-210181) (PMID:34219715)

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Abstract

Recent research suggests genetic variation in the Klotho locus may modify the association between APOE ɛ4 and cognitive impairment. We tested for associations and interactions between these genotypes versus risk of dementia, cognitive abilities, and brain structure in older UK Biobank participants. Klotho status was indexed with rs9536314 heterozygosity (versus not), in unrelated people with versus without APOE ɛ4 genotype, corrected for various confounders. APOE ɛ4 associated with increased risk of dementia, worse cognitive abilities, and brain structure. Klotho was associated with better reasoning. There were no interactions; potentially suggesting an age- and pathology-dependent Klotho effect.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Ward, Dr Joey and Flegal, Dr Kristin and Smith, Professor Daniel and Tank, Rachana and Lyall, Dr Donald
Authors: Tank, R., Ward, J., Celis-Morales, C., Smith, D. J., Flegal, K. E., and Lyall, D. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Journal of Alzheimer's Disease
Publisher:IOS Press
ISSN:1387-2877
ISSN (Online):1875-8908
Published Online:02 July 2021
Copyright Holders:Copyright © 2021 IOS Press
First Published:First published in Journal of Alzheimer's Disease 83(1): 51-55
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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