Relation between body composition, systemic inflammatory response, and clinical outcomes in patients admitted to an urban teaching hospital with COVID-19

McGovern, J., Dolan, R. , Richards, C., Laird, B. J., McMillan, D. C. and Maguire, D. (2021) Relation between body composition, systemic inflammatory response, and clinical outcomes in patients admitted to an urban teaching hospital with COVID-19. Journal of Nutrition, 151(8), pp. 2236-2244. (doi: 10.1093/jn/nxab142) (PMID:34159388) (PMCID:PMC8195217)

Abstract

Background: COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. Objectives: The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19. Methods: Patients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR , CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted. Results: Sixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P < 0.05). Thirty-day mortality was associated with high VFA (P < 0.05) and low SMI (P < 0.05). Conclusions: Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.

• Item Type: Articles
• Keywords: Body composition, obesity, sarcopenia, CT, COVID-19.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Maguire, Donogh and Dolan, Dr Ross and McMillan, Professor Donald and Laird, Dr Barry and McGovern, Mr Josh
• Authors: McGovern, J., Dolan, R., Richards, C., Laird, B. J., McMillan, D. C., and Maguire, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Nutrition
• Publisher: Oxford University Press
• ISSN: 0022-3166
• ISSN (Online): 1541-6100
• Published Online: 03 June 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Journal of Nutrition 151(8): 2236-2244
• Publisher Policy: Reproduced under a Creative Commons License