Optimal cut-off points for waist circumference in the definition of metabolic syndrome in Chile

Petermann-Rocha, F., Martínez-Sanguinetti, M. A., Ho, F. K., Celis-Morales, C. and Pizarro, A. (2020) Optimal cut-off points for waist circumference in the definition of metabolic syndrome in Chile. Public Health Nutrition, 23(16), pp. 2898-2903. (doi: 10.1017/S1368980020001469) (PMID:32618236)

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Abstract

Objective: To identify sex-specific cut-off points for waist circumference (WC) in the definition of metabolic syndrome (MetS) for the Chilean adult population. Design: MetS was defined as the presence of at least two out of four of the following criteria: TAG ≥1·7 mmol/l; HDL-cholesterol: <1·3 mmol/l in women and <1·0 mmol/l in men; systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; and fasting glucose ≥ 5·6 mmol/l or current treatment for diabetes. The receiver operating characteristics curve and the AUC were computed to derive the specificity and sensitivity using bootstrapping (10 000 iterations restricted to have at least between 40 and 60 % of the original population). The optimal cut-off point for the Chilean population was computed by sex. Setting: A representative sample of the Chilean population aged ≥15 years. Participants: 8182 participants (60 % women) from the three available Chilean National Health Surveys conducted in 2003, 2009–2010 and 2016–2017. Results: WC had a good predictive ability for MetS (AUC for men 0·74 (95 % CI 0·72, 0·76); AUC for women 0·71 (95 % CI 0·68, 0·73)). The optimal cut-off points for WC, in the definition of MetS, were 92·3 cm (95 % CI 90·5, 94·4) and 87·6 cm (95 % CI 85·8, 92·1) for men and women, respectively. Conclusions: The mentioned cut-off points should be used for WC in the definition of MetS in Chile. As a result, the current recommendation (WHO/International Diabetes Federation) for WC, in the identification of MetS, is not supported by these findings in a representative sample of the Chilean adult population.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Ho, Dr Frederick and Petermann, Mrs Fanny
Authors: Petermann-Rocha, F., Martínez-Sanguinetti, M. A., Ho, F. K., Celis-Morales, C., and Pizarro, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
Journal Name:Public Health Nutrition
Publisher:Cambridge University Press
ISSN:1368-9800
ISSN (Online):1475-2727
Published Online:03 July 2020
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Public Health Nutrition 23(16): 2898-2903
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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