Resident macrophages and their potential in cardiac tissue engineering

Suku, M., Forrester, L., Biggs, M. and Monaghan, M. G. (2022) Resident macrophages and their potential in cardiac tissue engineering. Tissue Engineering Part B: Reviews, 28(3), pp. 579-591. (doi: 10.1089/ten.TEB.2021.0036) (PMID:34088222)

Abstract

Many facets of tissue engineered models aim to understand cellular mechanisms to recapitulate in vivo behavior, study and mimic diseases for drug interventions and to provide better understanding towards improving regenerative medicine. Recent and rapid advances in stem cell biology, material science and engineering, have made the generation of complex engineered tissues much more attainable. One such tissue, human myocardium; is extremely intricate, with a number of different cell types. Recent studies have unraveled cardiac resident macrophages as a critical mediator for normal cardiac function. Macrophages within the heart exert phagocytosis and efferocytosis, facilitate electrical conduction, promote regeneration and remove cardiac exophers to maintain homeostasis. These findings underpin the rationale of introducing macrophages to engineered heart tissue, to more aptly capitulate in vivo physiology. Despite the lack of studies using cardiac macrophages in vitro, there is enough evidence to believe that they will be useful in making engineered heart tissues more physiologically relevant. In this review, we explore the rationale and feasibility of using macrophage as an additional cell source in engineered cardiac tissues.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Suku, Meenakshi
• Authors: Suku, M., Forrester, L., Biggs, M., and Monaghan, M. G.
• College/School: College of Science and Engineering
• Journal Name: Tissue Engineering Part B: Reviews
• Publisher: Mary Ann Liebert
• ISSN: 2152-4947
• ISSN (Online): 2152-4955
• Published Online: 04 June 2021
• Copyright Holders: Copyright © 2021 Meenakshi Suku, et al.
• First Published: First published in Tissue Engineering Part B: Reviews 28(3): 579-591
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
303533		EPSRC and SFI Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine	Matthew Dalby	Engineering and Physical Sciences Research Council (EPSRC)	EP/S02347X/1	Institute of Molecular, Cell & Systems Biology