Pre-clinical models of myocardial infarction: from mechanism to translation

Martin, T. P. , MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A. , Gray, G. A. and Loughrey, C. M. (2021) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, (doi: 10.1111/bph.15595) (PMID:34131903) (Early Online Publication)

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Abstract

Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Pre-clinical animal models have significantly advanced our understanding of MI and enable the development of therapeutic strategies to combat this debilitating disease. Notably, some drugs currently used to treat MI and heart failure (HF) in patients had initially been studied in pre-clinical animal models. Despite this, pre-clinical models are limited in their ability to fully recapitulate the complexity of MI in humans. The pre-clinical model must be carefully selected to maximise the translational potential of experimental findings. This review describes current experimental models of MI and considers how they have been used to understand drug mechanisms of action (MOA) and support translational medicine development.

Item Type:Articles
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Zaeri, Ali Abdullah I and O'Toole, Mr Dylan and MacDonald, Dr Eilidh and Martin, Dr Tamara and Nicklin, Professor Stuart and Elbassioni, Dr Ali Ali and Loughrey, Professor Christopher
Authors: Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., and Loughrey, C. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:British Journal of Pharmacology
Publisher:Wiley
ISSN:0007-1188
ISSN (Online):1476-5381
Published Online:15 June 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in British Journal of Pharmacology 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
308798Targeting RUNX to Attenuate Adverse Cardiac RemodellingChristopher LoughreyBritish Heart Foundation (BHF)RG/20/6/35095Vets - Veterinary Pathology, Public Health & Disease Investigation
301985Investigating the Therapeutic Potential of Runx1 for Myocardial InfarctionChristopher LoughreyBritish Heart Foundation (BHF)PG/18/9/33548CAMS - Cardiovascular Science
300489Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarctionStuart NicklinBritish Heart Foundation (BHF)PG/17/17/32877CAMS - Cardiovascular Science
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science