Martin, T. P. , MacDonald, E. A. , Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A. , Gray, G. A. and Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179(5), pp. 770-791. (doi: 10.1111/bph.15595) (PMID:34131903)
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Abstract
Approximately 7 million people are affected by acute myocardial infarction (MI) each year, and despite significant therapeutic and diagnostic advancements, MI remains a leading cause of mortality worldwide. Pre-clinical animal models have significantly advanced our understanding of MI and enable the development of therapeutic strategies to combat this debilitating disease. Notably, some drugs currently used to treat MI and heart failure (HF) in patients had initially been studied in pre-clinical animal models. Despite this, pre-clinical models are limited in their ability to fully recapitulate the complexity of MI in humans. The pre-clinical model must be carefully selected to maximise the translational potential of experimental findings. This review describes current experimental models of MI and considers how they have been used to understand drug mechanisms of action (MOA) and support translational medicine development.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | O'Toole, Mr Dylan and MacDonald, Dr Eilidh and Martin, Dr Tamara and Elbassioni, Dr Ali Ali and Loughrey, Professor Christopher and Nicklin, Professor Stuart and Zaeri, Ali Abdullah I |
Authors: | Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., and Loughrey, C. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | British Journal of Pharmacology |
Publisher: | Wiley |
ISSN: | 0007-1188 |
ISSN (Online): | 1476-5381 |
Published Online: | 15 June 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in British Journal of Pharmacology 179(5): 770-791 |
Publisher Policy: | Reproduced under a Creative Commons License |
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