Socioeconomic position links circulatory microbiota differences with biological age

Craven, H. et al. (2021) Socioeconomic position links circulatory microbiota differences with biological age. Scientific Reports, 11, 12629. (doi: 10.1038/s41598-021-92042-0) (PMID:34135381) (PMCID:PMC8209159)

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Abstract

Imbalanced nutrition is associated with accelerated ageing, possibly mediated by microbiota. An analysis of the circulatory microbiota obtained from the leukocytes of participants in the MRC Twenty-07 general population cohort was performed. We now report that in this cohort, the most biologically aged exhibit a significantly higher abundance of circulatory pathogenic bacteria, including Neisseria, Rothia and Porphyromonas, while those less biologically aged possess more circulatory salutogenic (defined as being supportive of human health and wellbeing) bacteria, including Lactobacillus, Lachnospiraceae UCG-004 and Kocuria. The presence of these salutogenic bactreria is consistent with a capacity to metabolise and produce Nrf2 agonists. We also demonstrate that associated one carbon metabolism, notably betaine levels, did not vary with chronological age, but displayed a difference with socioeconomic position (SEP). Those at lower SEP possessed significantly lower betaine levels indicative of a poorer diet and poorer health span and consistent with reduced global DNA methylation levels in this group. Our data suggest a clear route to improving age related health and resilience based on dietary modulation of the microbiota.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ellaway, Dr Anne and Galbraith, Dr Norman and Combet Aspray, Professor Emilie and Craven, Hannah and McGuinness, Dr Dagmara and Mcguinness, Dr David and Jones, Dr Brian and Buchanan, Dr Sarah and Shiels, Professor Paul and Ijaz, Dr Umer
Authors: Craven, H., McGuinness, D., Buchanan, S., Galbraith, N., Mcguinness, D. H., Jones, B., Combet, E., Mafra, D., Bergman, P., Ellaway, A., Stenvinkel, P., Ijaz, U. Z., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Scientific Reports
Publisher:Nature Research
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Scientific Reports 11: 12629
Publisher Policy:Reproduced under a Creative Commons License
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
727621SPHSU Core Renewal: Neighbourhoods and Communities Research ProgrammeAnne EllawayMedical Research Council (MRC)MC_UU_12017/10IHW - MRC/CSO SPHU
Office of the Chief Scientific Adviser (CSO)SPHSU10