Failure to detect an association with IL1 genotypes in European Caucasians with generalised early onset periodontitis

Hodge, P.J., Riggio, M.P. and Kinane, D.F. (2001) Failure to detect an association with IL1 genotypes in European Caucasians with generalised early onset periodontitis. Journal of Clinical Periodontology, 28(5), 430 -436. (doi:10.1034/j.1600-051x.2001.028005430.x)

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Publisher's URL: http://dx.doi.org/10.1034/j.1600-051x.2001.028005430.x

Abstract

OBJECTIVES: In order to elucidate the genetic background to EOP it is useful to investigate associations with genetic polymorphisms of immune response genes, whose products play a r le in the inflammatory process. The aim of this study was to examine IL1A and IL1B genetic polymorphisms in unrelated European white Caucasian patients with generalised early-onset periodontitis (GEOP). MATERIAL AND METHODS: Polymerase chain reaction (PCR) amplification of the ILIA (-889) gene and IL1B (+3953) gene (56 patients, 56 controls) was carried out and PCR products subjected to restriction fragment length polymorphism (RFLP) analysis. RESULTS: There were no significant differences between patients and controls for any of the genotype or allele frequencies investigated (p = 1.0). Smoking status was also included as a covariate but this did not alter the results. Furthermore, expression of the composite genotype described by Kornman and coworkers was also investigated in these subjects. No significant differences were found between patients and controls whether smoking was included as a covariate or not. CONCLUSION: The lack of any association between the IL1 polymorphisms and GEOP, in the population presented here, brings into doubt the usefulness of these candidate genes as markers of susceptibility to this form of periodontitis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hodge, Dr Penny and Riggio, Dr Marcello
Authors: Hodge, P.J., Riggio, M.P., and Kinane, D.F.
Subjects:R Medicine > RK Dentistry
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Journal of Clinical Periodontology
ISSN:0303-6979

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