Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products

Franz, L. and Koehnke, J. (2021) Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products. Chemical Communications, 57, pp. 6372-6375. (doi: 10.1039/D0CC06889F) (PMID:34075907)

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Abstract

Ribosomal natural products contain exquisite post-translational peptide modifications that are installed by a range of pathway-specific enzymes. We present proof of principle for a Sortase A-based approach that enables peptide modifcation by enzymes from unrelated pathways. This allowed the one-pot synthesis of a new-to-nature, hybrid ribosomal natural product.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Koehnke, Dr Jesko
Authors: Franz, L., and Koehnke, J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Chemical Communications
Publisher:Royal Society of Chemistry
ISSN:1359-7345
ISSN (Online):1364-548X
Published Online:24 May 2021
Copyright Holders:Copyright © 2021 The Royal Society of Chemistry
First Published:First published in Chemical Communications 57: 6372-6375
Publisher Policy:Reproduced under a Creative Commons License

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