What an interventionalist needs to know about MI with non-obstructive coronary arteries

Sykes, R. , Doherty, D., Mangion, K., Morrow, A. and Berry, C. (2021) What an interventionalist needs to know about MI with non-obstructive coronary arteries. Interventional Cardiology Review, 16, e10. (doi: 10.15420/icr.2021.10) (PMID:34188694) (PMCID:PMC8218171)

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Publisher's URL: https://doi.org/10.15420/icr.2021.10

Abstract

MI with non-obstructive coronary arteries (MINOCA) is caused by a heterogeneous group of vascular or myocardial disorders. MINOCA occurs in 5–15% of patients presenting with acute ST-segment elevation MI or non-ST segment elevation MI and prognosis is impaired. The diagnosis of MINOCA is made during coronary angiography following acute MI, where there is no stenosis ≥50% present in an infarct-related epicardial artery and no overt systemic aetiology for the presentation. Accurate diagnosis and subsequent management require the appropriate utilisation of intravascular imaging, coronary function testing and subsequent imaging to assess for myocardial disorders without coronary involvement. Although plaque-related MINOCA is currently managed with empirical secondary prevention strategies, there remains an unmet therapeutic need for targeted and evidence-based therapy for MINOCA patients and increased awareness of the recommended diagnostic pathway.

Item Type:Articles
Additional Information:CB is supported by research funding from the British Heart Foundation (PG/17/2532884, RE/13/5/30177, RE/18/6/34217). All other authors have no conflicts of interest to declare.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mangion, Dr Kenneth and Morrow, Dr Andrew and Sykes, Dr Robert and Doherty, Dr Daniel and Berry, Professor Colin
Authors: Sykes, R., Doherty, D., Mangion, K., Morrow, A., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Interventional Cardiology Review
Publisher:Radcliffe Cardiology
ISSN:1756-1477
ISSN (Online):1756-1485
Published Online:10 June 2021
Copyright Holders:Copyright © 2021 Radcliffe Cardiology
First Published:First published in Interventional Cardiology Review 16:e10
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
301454CORonary MICrovascular Angina (CorMicA): a pilot trial with a nested MRI sub-studyColin BerryBritish Heart Foundation (BHF)PG/17/25/32884CAMS - Cardiovascular Science
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science