Sepsis: when a simple infection becomes deadly

Farthing, A. G. et al. (2021) Sepsis: when a simple infection becomes deadly. Frontiers for Young Minds, 9, 639681. (doi: 10.3389/frym.2021.639681)

Abstract

The immune system plays a crucial role in maintaining a healthy body by working around the clock to recognize and respond to infection. Inflammation is part of the immune system’s protective response to an infection. The inflammatory response is incredibly powerful, so much so that it can damage the body’s cells if it is not tightly controlled. Sometimes, inflammation affects the whole body—this is called sepsis. The powerful and complex mechanisms in place to wipe out the infection can cause serious damage to healthy cells and tissues. Uncontrolled inflammation can cause irreversible damage to the body’s organs, such as the kidneys, eventually causing organs to shut down. If sepsis is not treated rapidly, it can lead to death. In this article, we describe the symptoms and diagnosis of sepsis and some of the current research being performed to better understand this dangerous process.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Howell, Jessie and Peveler, Dr William and Murphy, Dr Michael and Gracie, Dr Jennifer and Sajib, Mohammad Saiful Islam and Jimenez, Dr Melanie and Hammarton, Dr Tansy and Farthing, Andrew and Garrett, Miss Alice and Goodyear, Professor Carl and Forde, Dr Taya
• Authors: Farthing, A. G., Howell, J., Baillie, J. K., Forde, T., Garrett, A., Goodyear, C. S., Gracie, J., Graham, C., Hammarton, T. C., Murphy, M. E., Peveler, W. J., Pybus, S., Sajib, M. S. I., Thomson, G., and Jimenez, M.
• College/School: College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine; College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation; College of Science and Engineering > School of Chemistry; College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Frontiers for Young Minds
• Publisher: Frontiers Media
• ISSN: 2296-6846
• ISSN (Online): 2296-6846
• Published Online: 21 May 2021
• Copyright Holders: Copyright © 2021 Farthing, Howell, Baillie, Forde, Garrett, Goodyear, Gracie, Graham, Hammarton, Murphy, Peveler, Pybus, Sajib, Thomson and Jimenez
• First Published: First published in Frontiers for Young Minds 9:639681
• Publisher Policy: Reproduced under a Creative Commons Licence