Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens

Thomson, E. , Shah, R., Ahovegbe, L., Niebel, M. and Shepherd, J. (2021) Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens. Journal of Hepatology, 75(2), pp. 462-473. (doi: 10.1016/j.jhep.2021.04.045) (PMID:33974951) (PMCID:PMC8310923)

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Abstract

The hepatitis C virus (HCV) is an extremely diverse virus, subtypes of which are distributed variably around the world. Viral genotypes may be divided into epidemic subtypes; those that have become prevalent globally, and endemic subtypes that have a more limited distribution, mainly in Africa and Asia. The high variability of endemic strains reflects evolutionary origins in the locations where they are found. This increased genetic diversity raises the possibility of resistance to pan-genotypic direct acting antiviral regimens. While many endemic subtypes respond well to DAA therapies, others, for example genotypes 1l, 3b and 4r, do not respond as well as predicted. Many genotypes rare in high income countries but common in other parts of the world have not yet been fully assessed in clinical trials. Further sequencing and clinical studies in Sub-Saharan Africa and Asia are indicated to monitor response to treatment in order to facilitate the WHO 2030 elimination strategy.

Item Type:Articles
Additional Information:Financial support: Medical Research Council (MRC) (MC_UU_12014/1) and Wellcome Trust (102789/Z/13/A)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Professor Emma and Niebel, Mr Marc and Shepherd, Dr James
Authors: Thomson, E., Shah, R., Ahovegbe, L., Niebel, M., and Shepherd, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Hepatology
Publisher:Elsevier
ISSN:0168-8278
ISSN (Online):1600-0641
Published Online:08 May 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Journal of Hepatology 75(2): 462-473
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
172630Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9III-MRC-GU CVR Support Services
169538T-cell mediated evolution of hepatitis C virus during acute infectionEmma ThomsonWellcome Trust (WELLCOTR)102789/Z/13/ZIII-MRC-GU Centre for Virus Research