Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia

Trivett, C., Lees, Z. J. and Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75(12), pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9) (PMID:34131300)

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Abstract

Gestational diabetes mellitus (GDM) is a common disorder of pregnancy with short- and long-term consequences for mother and baby. Pre-eclampsia is of major concern to obstetricians due to its sudden onset and increased morbidity and mortality for mother and baby. The incidence of these conditions continues to increase due to widespread maternal obesity. Maternal obesity is a risk factor for GDM and pre-eclampsia, yet our understanding of the role of adipose tissue and adipocyte biology in their aetiology is very limited. In this article, available data on adipose tissue and adipocyte function in healthy and obese pregnancy and how these are altered in GDM and pre-eclampsia are reviewed. Using our understanding of adipose tissue and adipocyte biology in non-pregnant populations, a role for underlying adipocyte dysfunction in the pathological pathways of these conditions is discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Freeman, Dr Dilys and Trivett, Cara and Lees, Zoe
Authors: Trivett, C., Lees, Z. J., and Freeman, D. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:European Journal of Clinical Nutrition
Publisher:Springer Nature
ISSN:0954-3007
ISSN (Online):1476-5640
Published Online:15 June 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in European Journal of Clinical Nutrition 75(12): 1745-1756
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
309321BHF 4Yr PhD Studentship Award 2109Rhian TouyzBritish Heart Foundation (BHF)FS/19/56/34893CAMS - Cardiovascular Science