McArdle, P.A., Mir, K., Almushatat, A.S.K., Wallace, A.M., Underwood, M.A. and McMillan, D.C. (2006) Systemic inflammatory response, prostate-specific antigen and survival in patients with metastatic prostate cancer. Urologia Internationalis, 77(2), pp. 127-129.
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Abstract
<p><b>BACKGROUND:</b> It is increasingly recognised that, in cancer patients, disease progression is dependent on a complex interaction of the tumour and the host inflammatory response and that the systemic inflammatory response, as evidenced by an elevated C-reactive protein (CRP) concentration, may be a useful prognostic factor.</p> <p><b>MATERIALS AND METHODS:</b> The prognostic value of CRP compared with prostate-specific antigen (PSA) was examined in 62 patients with metastatic prostate cancer receiving androgen-deprivation therapy.</p> <p><b>RESULTS:</b> In all, 41 (66%) of patients died, 38 (61%) of their disease. On univariate survival analysis, PSA (p < 0.05) and CRP (p < 0.05) were significant predictors of cancer-specific survival. On multivariate analysis, both PSA (HR 1.96, 95% CI 1.00-3.83, p = 0.049) and CR (HR 1.97, 95% CI 0.99-3.92, p = 0.052) were independent predictors of cancer-specific survival. PSA concentrations were significantly correlated with those of CRP (r(s) = 0.46, p < 0.001).</p> <p><b>CONCLUSION:</b> The results of the present study suggest that, in patients with metastatic prostate cancer, the presence of an elevated CRP concentration predicts poor outcome, independent of PSA.</p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mir, Mr Khurram and McMillan, Professor Donald and Wallace, Dr Alan and Underwood, Mr Mark |
| Authors: | McArdle, P.A., Mir, K., Almushatat, A.S.K., Wallace, A.M., Underwood, M.A., and McMillan, D.C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | Urologia Internationalis |
| ISSN: | 0042-1138 |
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