Bonilha, C. S., Benson, R. A. , Scales, H. E. , Brewer, J. M. and Garside, P. (2021) Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation. Immunology Letters, 235, pp. 32-40. (doi: 10.1016/j.imlet.2021.05.001) (PMID:34000305)
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Abstract
The junctional adhesion molecule-A (JAM-A) is an adhesion molecule present in the surface of several cell types, such as endothelial cells and leukocytes as well as Dendritic Cells (DC). Given the potential relevance of JAM-A in diverse pathological conditions such as inflammatory diseases and cancer, we investigated the role of JAM-A in CD4+ T cell priming. We demonstrate that JAM-A is present in the immunological synapse formed between T cells and DC during priming. Furthermore, an antagonistic anti-JAM-A mAb could disrupt the interaction between CD4+ T cell and DC. Antagonism of JAM-A also attenuated T cell activation and proliferation with a decrease in T-bet expression and increased IL-6 and IL-17 secretion. These findings demonstrate a functional role for JAM-A in interactions between CD4+ T cells and DCs during T cell priming as a positive regulator of Th1 differentiation.
| Item Type: | Articles |
|---|---|
| Additional Information: | CSB was supported by CAPES Foundation, an agency under the Ministry of Education of Brazil (grant number 88881.129556/2016-01). CSB, RAB, HES, JMB and PG were supported by the Arthritis Research UK (ARUK) program grant number 19788 and the Innovative Medicines Initiative EU-funded project Be The Cure (BTCURE) [grant number 115142-2]. JMB and PG were also supported by the Research into Inflammatory Arthritis Center Versus Arthritis (RACE) (grant number 22072) . |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Benson, Dr Robert and Garside, Professor Paul and Brewer, Professor James and Scales, Dr Hannah and Bonilha, Mr Caio |
| Creator Roles: | Bonilha, C. S.Conceptualization, Investigation, Formal analysis, Writing – original draft Benson, R. A.Conceptualization, Investigation, Writing – review and editing Scales, H. E.Project administration, Writing – review and editing Brewer, J. M.Supervision, Funding acquisition, Writing – review and editing Garside, P.Funding acquisition, Writing – review and editing |
| Authors: | Bonilha, C. S., Benson, R. A., Scales, H. E., Brewer, J. M., and Garside, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Immunology Letters |
| Publisher: | Elsevier |
| ISSN: | 0165-2478 |
| ISSN (Online): | 1879-0542 |
| Published Online: | 14 May 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Immunology Letters 235:32-40 |
| Publisher Policy: | Reproduced under a Creative Commons Licence |
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