The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis

Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)

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β-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a meta-analysis was performed to assess the prognostic value of β-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between β-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5,475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear β-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous β-catenin expression was associated to poor OS. In conclusion, β-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.

Item Type:Articles
Additional Information:The authors gratefully acknowledge the Libyan government for funding.
Glasgow Author(s) Enlighten ID:Park, Mr James and Quinn, Dr Jean and Edwards, Professor Joanne and Matly, Mrs Amna and McMillan, Professor Donald
Authors: Matly, A., Quinn, J. A., McMillan, D. C., Park, J. H., and Edwards, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Critical Reviews in Oncology/Hematology
ISSN (Online):1879-0461
Published Online:13 May 2021
Copyright Holders:Copyright © 2021 Elsevier
First Published:First published in Critical Reviews in Oncology/Hematology 163: 103337
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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