Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)
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Abstract
β-catenin is a key component of Wnt signalling, which plays a crucial role in CRC progression. Therefore, a meta-analysis was performed to assess the prognostic value of β-catenin expression in CRC patients. PubMed and Web of Science were searched for relevant publications referring to the association between β-catenin expression and outcome of CRC patients. Review Manager version 5.4 was employed to analysis data from 28 eligible studies (containing 5,475 patients). Of these, 6 provided data on DFS, 6 provided data on CSS and 18 reports provided data on OS. High nuclear β-catenin expression was significantly associated with poorer DFS, CSS and OS in patients with CRC whereas, low membranous β-catenin expression was associated to poor OS. In conclusion, β-catenin has prognostic value and potential as a biomarker to stratify patients with CRC. However, further work with high quantity tissue cohorts and patient data is required to confirm this conclusion.
Item Type: | Articles |
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Additional Information: | The authors gratefully acknowledge the Libyan government for funding. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Park, Mr James and Quinn, Dr Jean and McMillan, Professor Donald and Matly, Mrs Amna and Edwards, Professor Joanne |
Authors: | Matly, A., Quinn, J. A., McMillan, D. C., Park, J. H., and Edwards, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Critical Reviews in Oncology/Hematology |
Publisher: | Elsevier |
ISSN: | 1040-8428 |
ISSN (Online): | 1879-0461 |
Published Online: | 13 May 2021 |
Copyright Holders: | Copyright © 2021 Elsevier |
First Published: | First published in Critical Reviews in Oncology/Hematology 163: 103337 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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