Genomes of anguillid herpesvirus 1 strains reveal evolutionary disparities and low genetic diversity in the genus cyprinivirus

Donohoe, O., Zhang, H., Delrez, N., Gao, Y., Suárez, N. M., Davison, A. J. and Vanderplasschen, A. (2021) Genomes of anguillid herpesvirus 1 strains reveal evolutionary disparities and low genetic diversity in the genus cyprinivirus. Microorganisms, 9(5), 998. (doi: 10.3390/microorganisms9050998) (PMID:34063135) (PMCID:PMC8148134)

[img] Text
241114.pdf - Published Version
Available under License Creative Commons Attribution.

5MB

Abstract

Anguillid herpesvirus 1 (AngHV-1) is a pathogen of eels and a member of the genus Cyprinivirus in the family Alloherpesviridae. We have compared the biological and genomic features of different AngHV-1 strains, focusing on their growth kinetics in vitro and genetic content, diversity, and recombination. Comparisons based on three core genes conserved among alloherpesviruses revealed that AngHV-1 exhibits a slower rate of change and less positive selection than other cypriniviruses. We propose that this may be linked to major differences in host species and corresponding epidemiological circumstances. Efforts to derive evolutionary rate estimates for cypriniviruses under various theoretical models were ultimately unrewarding. We highlight the potential value of future collaborative efforts towards generating short-term evolutionary rate estimates based on known sequence sampling dates. Finally, we revealed that there is significantly less genetic diversity in core gene sequences within cyprinivirus species clades compared to species in the family Herpesviridae. This suggests that cyprinivirus species may have undergone much more vigorous purifying selection post species clade divergence. We discuss whether this may be linked to biological and anthropogenic factors or to sampling bias, and we propose that the comparison of short-term evolutionary rates between species may provide further insights into these differences.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Suarez, Dr Nicolas and Davison, Professor Andrew
Creator Roles:
Suárez, N. M.Data curation, Methodology
Davison, A. J.Formal analysis, Funding acquisition, Investigation, Writing – review and editing
Authors: Donohoe, O., Zhang, H., Delrez, N., Gao, Y., Suárez, N. M., Davison, A. J., and Vanderplasschen, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Microorganisms
Publisher:MDPI
ISSN:2076-2607
ISSN (Online):2076-2607
Published Online:05 May 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Microorganisms 9(5): 998
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH