Risk of mortality among inpatients with COVID-19 and type 2 diabetes: national data from Kuwait

Al-Ozairi, E. et al. (2021) Risk of mortality among inpatients with COVID-19 and type 2 diabetes: national data from Kuwait. Endocrinology, Diabetes and Metabolism, (doi: 10.1002/edm2.287) (Early Online Publication)

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Abstract

Introduction To investigate type 2 diabetes as a risk factor for COVID-19 death following hospital admission in Kuwait. Methods A retrospective cohort study using data from a central hospital that cared for all hospitalized COVID-19 patients in Kuwait. We investigated the association between type 2 diabetes, with COVID-19 mortality using multiply imputed logistic regression and calculated the population attributable fraction. Results A total of 5333 patients were admitted with COVID-19, of whom 244 died (4.6%). Diabetes prevalence was 24.8%, but 53.7% of those who died had diabetes. After adjusting for age, sex, ethnicity and other comorbidities, diabetes was associated with death (OR 1.70 [95% CI 1.23, 2.34]) and admission to the intensive care unit more than 3 days after initial admission (OR 1.78 [95% CI 1.17, 2.70]). Assuming causality, the population attributable fraction for type 2 diabetes in COVID-19 death was 19.6% (95% CI 10.8, 35.6). Conclusion Type 2 diabetes is a strong risk factor for COVID-19 death in the Middle East. Given the high prevalence of type 2 diabetes in the Middle East, as well as many Western countries, the public health implications are considerable.

Item Type:Articles
Keywords:COVID-19, death, diabetes.
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gill, Professor Jason and Katikireddi, Professor Vittal and Brown, Miss Rosemary and Welsh, Dr Paul and Alabdullah, Lulwa and Celis, Dr Carlos and Gray, Dr Stuart and Sattar, Professor Naveed
Authors: Al-Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., Alsaeed, D., Al Ozairi, A., Hasan, A., Al-Mulla, F., Katikireddi, S. V., Gray, S. R., Gill, J. M.R., Celis-Morales, C. A., Sattar, N., and Welsh, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO SPHSU
Journal Name:Endocrinology, Diabetes and Metabolism
Publisher:Wiley
ISSN:2398-9238
ISSN (Online):2398-9238
Published Online:10 July 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Endocrinology, Diabetes and Metabolism 2021
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceRhian TouyzBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science
304005MRC Precision Medicine Training GrantMorven BarlassMedical Research Council (MRC)MR/N013166/1CAMS - Cardiovascular Science
172690Understanding the impacts of welfare policy on health: A novel data linkage studySrinivasa KatikireddiOffice of the Chief Scientific Adviser (CSO)SCAF/15/02HW - Public Health
Inequalities in healthMedical Research Council (MRC)MC_UU_00022/2HW - MRC/CSO Social and Public Health Sciences Unit
Chief Scientist Office (CSO)SPHSU17