New developments in RiPP discovery, enzymology and engineering

Montalbán-López, M. et al. (2021) New developments in RiPP discovery, enzymology and engineering. Natural Product Reports, 38(1), pp. 130-239. (doi: 10.1039/D0NP00027B) (PMID:32935693)

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Abstract

Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the meeting participants assembled the current review describing new developments since 2013. The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates. In addition, genome mining tools used for RiPP discovery are discussed as well as various strategies for RiPP engineering. An outlook section presents directions for future research.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Koehnke, Dr Jesko
Authors: Montalbán-López, M., Scott, T. A., Ramesh, S., Rahman, I. R., van Heel, A. J., Viel, J. H., Bandarian, V., Dittmann, E., Genilloud, O., Goto, Y., Grande Burgos, M. J., Hill, C., Kim, S., Koehnke, J., Latham, J. A., Link, A. J., Martínez, B., Nair, S. K., Nicolet, Y., Rebuffat, S., Sahl, H.-G., Sareen, D., Schmidt, E. W., Schmitt, L., Severinov, K., Süssmuth, R. D., Truman, A. W., Wang, H., Weng, J.-K., van Wezel, G. P., Zhang, Q., Zhong, J., Piel, J., Mitchell, D. A., Kuipers, O. P., and van der Donk, W. A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Natural Product Reports
Publisher:Royal Society of Chemistry
ISSN:0265-0568
ISSN (Online):1460-4752
Published Online:16 September 2020

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