Arps: actin-related proteins

Machesky, L. M. and May, R. C. (2001) Arps: actin-related proteins. In: dos Remedios, G. and Thomas, D.D. (eds.) Molecular Interactions of Actin. Springer. ISBN 9783540671107 (doi:10.1007/978-3-540-46560-7_15)

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Abstract

The Arps (actin-related proteins) constitute a recently discovered family of proteins related to actin in sequence and probably 3D structure. Although their roles in the cell are diverse, many of the Arps function as subunits of multiprotein complexes. Arp1 is found in a 20-S complex (with at least seven different proteins) which regulates cytoplasmic dynein-based microtubulemembrane interactions. Arp2 and Arp3 function in an 8.5-S protein complex that can initiate actin polymerization, as well as cross-linking and capping actin filaments. Arp7 and Arp9 are components of the 2000-kDa SWI/SNF complex that is thought to regulate chromatin structure to alleviate transcriptional repression. There are several other members of the Arp family (up to ten family members in budding yeast) whose functions are less well-characterized (Fig. 1), but it seems that Arps generally have diverse functions and in some cases maybe related to actin only in sequence and structure rather than in function. The Hsc70 family and some sugar kinases also show a significant structural similarity to actin, but are not included as Arps because they do not share significant primary sequence homology (Schroer et al. 1994).

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Machesky, L. M., and May, R. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Publisher:Springer
ISBN:9783540671107
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